Seoul National University

Bs Research Co. Ltd.

Mojeon Industrial. Co., Ltd.

Yan Lee

Seonju Lee

Jaehoon Yu

Ji Ung Park

Suk Wha Kim

Ji Yeon Ham

Hee Jin Kim

Hye Jeong Min

Soonsil Hyun

Tae Hyun Choi

Heejin Kim

Byeong Moon Kim

Seo Yeon Kim

Dongwook Jung

Eun Joung Choi

Daichi Nakayama

Yeongbong Mok

Minwoo Noh

Doyeon Jo

Yunhwa Choi

Sun Mi Jin

Disclosed are a method for preparing a biomaterial having selectively functionalized tyrosine, a biomaterial having selectively functionalized tyrosine, and a pharmaceutical composition containing same as an active ingredient. The method for preparing a biomaterial to which a compound represented by chemical formula 2 is coupled, of the present invention, allows the compound represented by chemical formula 2 to be selectively coupled, in a high yield in a biomaterial, to tyrosine, which is present on the surface of an aqueous solution such that the coupling thereof to amino acids other than tyrosine does not occur and, when only one tyrosine is present, heterogeneous mixtures are not present and the inherent activity of the biomaterial is maintained, and thus the compound can be effectively used as a pharmaceutical composition containing a biomaterial drug as an active ingredient. In addition, the method can selectively functionalize tyrosine, and thus can be effectively used for tyrosine functionalization in a biomaterial.

Method for preparing biomaterial having selectively functionalized tyrosine, biomaterial having selectively functionalized tyrosine, and pharmaceutical composition containing same as active ingredient

The present invention relates to a coating composition for an in-vivo implantable prosthesis including a photoinitiator, a crosslinking agent, and a phosphorylcholine (pc) monomer having an acrylate group, a method of coating an in-vivo implantable prosthesis using the coating composition, and a cosmetic prosthesis coated with the crosslinked polyphosphorylcholine. An in-vivo implantable prosthesis coated with crosslinked polyphosphorylcholine may be manufactured by a simple method of applying a coating composition including a photoinitiator, a crosslinking agent, and a phosphorylcholine (pc) monomer having an acrylate group according to the present invention, and then irradiating uv rays. The crosslinked polyphosphorylcholine coating may provide hydrophilicity for the surface and may also remarkably reduce adsorption of proteins and fibroblasts, which may cause side effects such as capsular contracture. Further, the coating has strong enough not to peel off even under stimulation, and therefore, it is maintained under vigorous activity after implantation, thereby being usefully applied to the manufacture of an in-vivo implantable prosthesis with reduced side effects, such as breast prosthesis for cosmetic surgery.

Prosthesis for in vivo insertion, coated with cross-linked polyphosphorylcholine

An anti-seismic performance reinforcement structure of a masonry structure and a construction method of the same are proposed, where a deformed bar is constructed to be tied to the entire circumference of the masonry structure at every predetermined height thereof such that the masonry structure is connected to a wall, thereby simplifying a construction process, and inducing the masonry structure and the wall to be moved integrally to each other during an earthquake so as to prevent the masonry wall from collapsing. The method of performing anti-seismic performance reinforcement and crack repair of the masonry structure includes: removing a predetermined depth of a horizontal joint; mounting the cross joint by forcibly press-fitting the cross joint having the press-in holder and the horizontal holder to a perforated position; fixing a deformed bar fixture to the wall; and tying the entire circumference of the masonry structure with the deformed bar.

Anti-seismic performance reinforcement and crack repair structure of masonry structure and construction method of same

The present invention relates to a coating composition for an in-vivo implantable prosthesis including a photoinitiator, a crosslinking agent, and a phosphorylcholine (PC) monomer having an acrylate group, a method of coating an in-vivo implantable prosthesis using the coating composition, and a cosmetic prosthesis coated with the crosslinked polyphosphorylcholine. An in-vivo implantable prosthesis coated with crosslinked polyphosphoryicholine may be manufactured by a simple method of applying a coating composition including a photoinitiator, a crosslinking agent, and a phosphorylcholine (PC) monomer having an acrylate group according to the present invention, and then irradiating UV rays. The crosslinked polyphosphorylcholine coating may provide hydrophilicity for the surface and may also remarkably reduce adsorption of proteins and fibroblasts, which may cause side effects such as capsular contracture. Further, the coating has strong enough not to peel off even under stimulation, and therefore, it is maintained under vigorous activity after implantation, thereby being usefully applied to the manufacture of an in-vivo implantable prosthesis with reduced side effects, such as breast prosthesis for cosmetic surgery.

The present invention relates to a broken or kinked helical peptide or peptide analogue and the use thereof, and more particularly to a Gram-negative bacterial membrane-penetrating peptide or peptide analogue wherein an alpha-helical amphipathic peptide composed of hydrophobic amino acids and hydrophilic amino acids has a kinked structure, or an antimicrobial composition employing the specific activity of the peptide against the Gram-negative bacterial membrane, or an antimicrobial composition for co-administration, or a conjugate comprising a drug linked to the peptide or peptide analogue, or an antibiotic comprising the same.

Broken or folded helical peptide or peptide analog exhibiting antimicrobial activity against gram-negative bacteria, and use thereof

The present invention relates to a stapled peptide, a preparation method thereof and the use thereof, and more specifically to an amphipathic alpha-helical stapled peptide comprising hydrophobic amino acids and hydrophilic amino acids, a preparation method thereof, and the use thereof for intracellular delivery of an active substance.

Cell penetrating stapled peptide, manufacturing method therefor, and use thereof

The present invention relates to a thermo-responsive draw solute that can be applied to water desalination and purification based on forward osmosis. The thermo-responsive draw solute has a molar mass of 50 to 3000 g/mol and undergoes a phase transition at a temperature of 0&#xb0; C. to 70&#xb0; C. The thermo-responsive draw solute creates optimum conditions for the desalination of seawater and the purification of contaminated water based on forward osmosis. The present invention also relates to a method for water desalination and purification using the thermo-responsive draw solute. The method consumes little energy for water desalination or purification, is simple to apply to water desalination or purification, and enables separation of the draw solute in a very easy manner.

Thermo-responsive draw solute for forward osmosis and method for water desalination and purification using the same

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Seoul, South Korea

Yan Lee