Eisai R&d Management Co., Ltd.

Eisai Company, Limited

Yan (Janet) Zhao

Toshihiko Kaneko

Mark Spyvee

Seiichi Kobayashi

Kenzo Muramoto

Kouichi Kikuchi

Motohiro Soejima

Ieharu Hishinuma

Boris M Seletsky

Heather Davis

Yimin Jiang

Wanjun Zheng

André Lescarbeau

Norihito Ohi

Xiang-Yi Li

Bruce Decosta

Fabian Gusovsky

Hiromitsu Yokohama

Marc Pesant

Ye Yao

Lynda Tremblay

Jane Daun

The present invention provides compounds having formula (I): 

Deazapurines and uses thereof

As discussed above, there remains a need for the development of novel therapeutic agents useful for treating inflammatory or autoimmune and proliferative diseases. The present invention provides novel compounds of general formula (I), and pharmaceutical compositions thereof, as described generally and in classes and subclasses herein, as well as methods of making and using such compounds.

The present invention provides compounds having formula (I), wherein R, R, Rand n are as described generally and in classes and subclasses herein, and additionally provides pharmaceutical compositions thereof, and methods for the use thereof in the treatment of inflammatory or autoimmune and proliferative disorders and as inhibitors of cell adhesion molecule expression and inflammatory cytokine signal transduction generally 

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North Andover, MA, United States of America

Yan (Janet) Zhao