University of Massachusetts

Yan Hu

Raffi Van Aroian

Compositions and methods for treating or reducing the severity or likelihood of occurrence of a parasitic worm or helminth infection in a subject are described. The methods include administering to the subject a therapeutically effective amount of a recombinant bacterium expressing a crystal protein such as acrystal protein (Cry). The crystal proteins may be full length, truncated, variant, or sub-variant Cry proteins. Examples of crystal proteins include Cry5B, Cry21, Cry14A, Cry6A, and Cry13A. The recombinant bacterium may be, for example, aor other Gram-positive bacterium, for instance, a lactic acid fermenting bacterium such asor. Related compositions and recombinant microorganisms are also described.

Growing community of inventors

Shrewsbury, MA, United States of America

Yan Hu