Alibaba Group Holding Limited

Glaxosmithkline Intellectual Property Development Limited

Shanghai Microport Medical (Group) Co., Ltd.

Yan Hu

Mui Cheung

Chengde Wu

Qiyi Luo

Jeffrey Michael Axten

Huiping Amy Guan

Michael P DeMartino

Peng Huang

Xu Cai

Jupeng Xia

Donghui Qin

Zhirong Tang

Xiaoling Li

Junfei Li

Zhiliu Zhang

Chengyun Yue

Dadong Zhang

Aaron Bayne Miller

Xiaojuan Lin

Junkui Li

This invention relates to novel compounds according to Formula (I) which are inhibitors of furin, to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the treatment of fibrotic diseases, including pulmonary fibrosis, renal fibrosis, liver fibrosis, skin fibrosis, ocular fibrosis, cardiac fibrosis, and other miscellaneous fibrotic conditions. The disclosed compounds may also be useful for treating other furin-mediated conditions, including but not limited to, hypertension, cancer, infectious diseases, and genetic disorders (e.g., cystic fibrosis (CF)), and neurodegenerative disorders.

Furin inhibitors

Extracting characteristic information includes receiving a collection command from a client, obtaining, via a collection device, biometric information based on the collection command, selecting a stored extraction algorithm corresponding to the client, the stored extraction algorithm being selected from among a plurality of stored extraction algorithms, extracting characteristic values from the obtained biometric information, the characteristic values being extracted based on the selected extraction algorithm, and sending the extracted characteristic values to the client.

Method and system for extracting characteristic information

An interventional medical device and manufacturing method thereof. The interventional medical device comprises: a stent body (); a surface of the stent body () being provided with a drug releasing structure (), and drug in the drug releasing structure () being drug for suppressing proliferation of adventitial fibroblasts and a drug for suppressing proliferation of intimal and/or smooth muscle cells. In use, after interventional medical device is implanted into a human body, the drug for suppressing proliferation of adventitial fibroblasts carried thereon can promote the compensatory expansion of the vessel, and the drug for suppressing proliferation of intimal cells and/or smooth muscle cells carried thereon can suppress intimal proliferation of the vessel. The combination of the two kinds of drugs greatly reduces the occurrence rate of in-stent restenosis.

Interventional medical device and manufacturing method thereof

Growing community of inventors

Shanghai, China

Yan Hu