Tsinghua University

Protgen Ltd.

Beijing Baidu Netcom Science and Technology Co., Ltd.

Beijing Protgen Ltd.

Beijing Baidu Netcom Science Technology Co., Ltd

Yantai Protgen Biotechnology Development Co., Ltd.

Yan Fu

Yongzhang Luo

Wei Zhuo

Lianghui Chen

Peng Liu

Lei Gao

Yang Chen

Fei Wu

Guodong Chang

Xiaofeng Wang

Xiaomin Song

Yangjie Zhou

Jun Fang

Xinan Lu

Daifu Zhou

Lin Jia

Huadong Tang

Shunnan Xu

Lu Gan

Qing Han

Quanbin Wang

Liangang Peng

Xiaoxuan Yang

Qingxin Lei

Michuan Li

Chuntao Lu

Shuling Yang

Dawei Cui

A method includes: sending, by one or more computers, in response to the number of data providers for federated learning being greater than a first threshold, a data field required for the federated learning to a coordinator, the coordinator comprising a computer; receiving, by one or more computers, from the coordinator, information about one or more data providers comprising the required data field, for determining the data providers comprising the required data field as the remaining data providers, wherein the coordinator stores a data field of each data provider; and performing, by one or more computers, federated learning-based modeling with each of the remaining data providers.

Federated learning for improving matching efficiency

A method, electronic device and storage medium for item recommendation and for model training, which relates to the field of artificial intelligence, are disclosed. According to some embodiments: an item feature expression database is created using a pre-trained user-clicking-item task model and at least two pieces of feature information of items in the repository of items to be recommended; a feature expression of a user is obtained using the pre-trained user-clicking-item task model and at least two pieces of feature information of the user; identifiers of N items to be recommended are obtained according to the feature expression of the user and the item feature expression database; relevant information of the N items is recommended to the user based on the identifiers of the N items.

Method, electronic device and storage medium for item recommendation

The disclosure provides an image clustering method and an image clustering apparatus. The method includes: obtaining new images, and clustering the new images to obtain a first cluster; determining a historical cluster similar to the first cluster as a second cluster from existing historical clusters; obtaining a distance between the first cluster and the second cluster; and generating a target cluster by fusing the first cluster and the second cluster based on the distance. In the image clustering method, with the image clustering apparatus of the disclosure, secondary clustering processing performed on the existing historical clusters based on newly added images is not required, new and old clusters are directly fused.

Image clustering method and apparatus, and storage medium

The present invention discloses a new anti-tumor medicament comprising a mutant of endostatin. The mutant comprises a mutation in the ATP-binding site of endostatin and has a decreased ATPase activity and an increased anti-angiogenesis activity.

Endostatin mutants with mutations at ATP binding sites

The present invention relates to a method of identifying cancer subjects, in particular human patients, who are suitable for anti-lymphangiogenesis therapy to prevent tumor growth and tumor metastasis. The present invention also relates to a new approach, which uses nucleolin as a bait to search and screen for lymphangiogenesis inhibitors or cancer suppressors, which function in a manner that is analogous to endostatin. The invention is based upon the discovery that nucleolin is specifically expressed on lymphangiogenic vessels and functions as a specific receptor for endostatin, and thus is involved in the signal transduction pathway of endostatin as an anti-lymphangiogenesis inhibitor. The present invention also discloses that cell surface nucleolin on lymphatic endothelial cells is a biomarker for lymphangiogenic vessels, which could be used for the prediction of tumor metastasis.

Use of nucleolin as a biomarker for lymphangiogenesis in a cancer prognosis and therapy

The present invention relates to the diagnosis and treatment of cancer, and specifically to a method of diagnosing the presence, status or metastasis of cancer by detecting plasma Hsp90&#x3b1; having the amino acid sequence of SEQ ID NO:1 as a tumor marker. In addition, the present invention also relates to a method for the treatment of cancer and metastasis.

Method of inhibiting or treating cancer metastasis

The present invention relates to a new use of a known medicament. Specifically, the invention relates to methods and compositions for enhancing the therapeutic efficacy of a therapeutic agent by increasing the uptake of the therapeutic agent by target cells, and in particular relates to a pharmaceutical composition comprising a regulating agent of lipid raft/caveolae-dependent endocytic pathway and some therapeutic agents, such as anti-tumor agents. The invention also relates to a method for screening a regulating agent of lipid raft/caveolae-dependent endocytic pathway capable of enhancing the therapeutic efficacy of anti-tumor agents.

Methods and compositions for enhancing the uptake of therapeutic agents by target cells

The invention provides the uses of fibrinogen-420 or alpha EC domain thereof, for inhibiting protein aggregation, refolding the denatured proteins, manufacturing drugs for prevention and/or treatment of protein misfolding diseases, resisting protein denaturation, and detecting the quality of protein products. The invention also provides the drugs for prevention and/or treatment of protein misfolding diseases or protein denatured disease, and the protein stabilizer. The active ingredient of the said drugs and stabilizer is fibrinogen-420 or alpha EC domain thereof.

Application of fibrinogen-420 and its active domain

Method for cancer detection

The present invention relates to the diagnosis and treatment of cancer, and specifically to a method of diagnosing the presence or metastasis of cancer by detecting plasma Hsp90&#x3b1; having the amino acid sequence of SEQ ID No. 1 as a tumor marker. In addition, the present invention also relates to a method for the treatment of cancer and metastasis.

Tumor biomarker

Growing community of inventors

Beijing, China

Yan Fu