The Gillette Company

Other

Yan-Fei Shen

Angel L Carrillo

Richard Oryszczak

Tuan M Vu

Jayant N Sane

Jan L Allen

Craig M Coe

Yuling Yin

The present invention relates to enhanced efficacy antiperspirant salts containing strontium and an amino acid or a hydroxy acid and particularly to stabilized aqueous solutions of such salts. The present invention also embraces methods of making these antiperspirant salts and solutions and compositions containing same.

Enhanced efficacy antiperspirant compositions containing strontium

Disclosed are enhanced efficacy aluminum-zirconium antiperspirant salt compositions that have a metal (Al+Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. These salts also typically exhibit an HPLC peak 5 area content of about 33% or more, preferably at least 45%, more preferably at least 50%, most preferably at least 55%. Especially preferred are aluminum-zirconium antiperspirant salt compositions which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4, preferably at least 0.7. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant salt compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminum-zirconium antiperspirant salt composition as described above.

Aluminum-zirconium antiperspirant salts with low M:CI ratio

Disclosed is a liquid aqueous alcoholic antiperspirant composition comprising, by weight, about 10% to about 60% ethanol, water, and about 8% to about 22% (USP) antiperspirant salt dissolved in the composition, wherein said antiperspirant salt comprises a calcium enhanced aluminum-zirconium chlorohydrate. The composition may optionally include a thickening agent to increase the viscosity of the solution. A more viscous solution is less prone to dripping from the skin or leaking from the dispensing container. Ideally, the composition will provide an absolute sweat reduction significantly higher than currently available antiperspirant products, typically at least 60% sweat reduction or higher.

Aqueous alcoholic antiperspirant composition containing calcium enhanced antiperspirant salt

Disclosed are enhanced efficacy antiperspirant compositions containing a strontium salt and/or a calcium salt. In particular, there is disclosed an antiperspirant composition comprising a dermatologically acceptable carrier vehicle, about 8% to about 22% (USP) of an aluminum-zirconium chlorohydrate-gly antiperspirant salt, wherein the antiperspirant salt has an HPLC peak 5 area of at least 33%, and about 0.5% to about 15%, preferably about 1% to about 6%, by weight, of a water soluble salt selected from the group consisting of a water soluble strontium salt, a water soluble calcium salt and a mixture thereof. It has been found that the inclusion of a strontium salt and/or a calcium salt boosts the efficacy of a high peak 5 antiperspirant salt. As a preferred feature, the antiperspirant salt and the water soluble salt are dissolved in at least a portion of the carrier vehicle.

Enhanced efficacy antiperspirant compositions containing strontium or calcium

Disclosed are antiperspirant compositions, particularly clear gel antiperspirant compositions, that are water-in-silicone oil emulsions. The emulsion includes a water phase, typically comprising about 65% to about 95% by weight of the emulsion, and a silicone oil phase, typically comprising about 5% to about 35% by weight of the emulsion. The water phase includes an antiperspirant salt dissolved therein, typically in an amount of about 8% to about 30% by weight of the emulsion, the antiperspirant salt comprising a calcium enhanced aluminum-zirconium chlorohydrate. The silicone oil phase contains less than about 5% by weight of the emulsion of a non-volatile oil and includes about 2% to about 25% by weight of the emulsion of a volatile linear silicone.

Gel antiperspirant composition containing volatile linear silicone and calcium enhanced antiperspirant salt

Disclosed is an anhydrous topical antiperspirant composition comprising a dermatologically acceptable carrier and a perspiration reducing effective amount of a particulate antiperspirant salt suspended in the carrier. The antiperspirant salt comprises an aluminum-zirconium chlorohydrate having a metal to chloride ratio between about 0.9 and about 1.3. The composition also includes, separate from the antiperspirant salt, a stabilizing basic material in an amount sufficient to prevent degradation of the antiperspirant composition or to minimize acid odor. Also disclosed is a method of reducing perspiration from human skin by applying the aforementioned topical composition.

Stabilized antiperspirant compositions containing aluminum-zirconium salts with low M:Cl ratio

Disclosed are enhanced efficacy aluminum-zirconium chlorohydrate antiperspirant salts having a metal (Al&plus;Zr) to chloride ratio of about 0.9 to about 1.2, preferably about 0.9 to about 1.1, most preferably about 0.9 to about 1.0. To achieve the highest possible antiperspirant efficacy, these salts are made with or include a zirconium hydroxychloride of the formula Zr(OH) Cl wherein b is about 2.8 to about 4.0, preferably about 3.2 to about 4.0, so that the Zr:Cl ratio in said zirconium hydroxychloride is about 0.36 to about 0.25, preferably about 0.31 to about 0.25. The present invention also embraces methods of making such antiperspirant salts and aqueous solutions of such antiperspirant salts. The present invention further embraces topical compositions comprising a dermatologically acceptable carrier and a perspiration reducing effective amount of an aluminum-zirconium antiperspirant salt as described above.

Aluminum-zirconium antiperspirant salts made with zirconium salts having low Zr:Cl ratio

Disclosed are enhanced efficacy aluminum-zirconium antiperspirant salt compositions which exhibit an HPLC peak 5 area content of about 33% or more, preferably at least 45%, more preferably at least 50%, most preferably at least 55%. Especially preferred are aluminum-zirconium antiperspirant salt compositions which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4, preferably at least 0.7. The aforementioned salt compositions will preferably have a metal (Al&plus;Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant salt compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminum-zirconium antiperspirant salt composition as described above.

Aluminum-zirconium antiperspirant salts with high peak 5 Al content

Disclosed are enhanced efficacy aluminum-zirconium antiperspirant salt compositions which exhibit an HPLC peak 5 area content of about 33% or more. Especially preferred are aluminum-zirconium antiperspirant salt compositions which, in addition to the aforementioned high peak 5 content, also exhibit an HPLC peak 4 to peak 3 area ratio of at least 0.4. The aforementioned salt compositions will preferably have a metal (Al&plus;Zr) to chloride (or anion) ratio of about 0.90 to about 1.00. Also disclosed are methods of making such antiperspirant salt compositions and aqueous solutions of such antiperspirant salt compositions. Further disclosed are topical compositions comprising a dermatologically acceptable carrier vehicle and a perspiration reducing effective amount of an aluminum-zirconium antiperspirant salt composition as described above.

Aluminum-zirconium antiperspirant salts with high peak 5 al content

The present invention relates to enhanced efficacy antiperspirant salts containing calcium and an amino acid or a hydroxy acid and particularly to stabilized aqueous solutions of such salts. The present invention also embraces methods of making these antiperspirant salts and solutions and compositions containing same.

Enhanced antiperspirant salts stabilized with calcium and concentrated aqueous solutions of such salts

The present invention relates to methods of making enhanced efficacy antiperspirant salts and particularly stabilized aqueous polyhydric alcohol solutions of such salts. One such method involves stabilizing an aqueous solution of an enhanced efficacy antiperspirant salt by adding an effective amount of a polyhydric alcohol having from 3 to 6 carbon atoms and from 3 to 6 hydroxyl groups. A second disclosed method involves preparing an enhanced efficacy aluminum antiperspirant salt by heating an aqueous solution of an aluminum antiperspirant salt in the presence of a polyhydric alcohol having from 3 to 6 carbon atoms and from 3 to 6 hydroxyl groups at a temperature of at least 50.degree. C. for a time sufficient to convert the salt to an enhanced salt. A third disclosed method is an improvement in the method of making an aluminum hydroxy halide or an aluminum hydroxy nitrate by reacting aluminum with an aqueous solution of aluminum halide or aluminum nitrate (or with aqueous hydrogen halide or nitric acid), wherein the improvement comprises including a polyhydric alcohol having from 3 to 6 carbon atoms and from 3 to 6 hydroxyl groups in the reaction mixture. Also disclosed are compositions produced by the foregoing methods.

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Canton, MA, United States of America

Yan-Fei Shen