Nikang Therapeutics, Inc.

Xuzhou University of Technology

Yan Dong

Yan Lou

Lei Liu

Jiping Fu

Lei Zhang

Yigang He

Qian Wang

Chuanhui Huang

Charles M Cook

Rongzhen Chen

The present disclosure provides certain processes of making 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)-benzonitrile (Compound 1) and certain polymorphs thereof. Also provided are pharmaceutical compositions comprising a crystalline polymorph form of Compound 1 and processes for preparing such polymorph forms.

Processes of making 3-fluoro-5-(((1S,2aR)-1,3,3,4,4-pentafluoro-2a-hydroxy-2,2a,3,4-tetrahydro-1H-cyclopenta[cd]inden-7-yl)oxy)-benzonitrile and polymorphs thereof

A load-sensitive multi-path valve testing device includes the first, second, and third pressure sensors connected to the T, P, and LS ports of the load-sensitive multi-path valve; an oil outlet of an electronically controlled variable displacement pump connected to the P port of the load-sensitive multi-path valve via an oil supply pipeline; a first proportional relief valve and a first flow sensor connected on the oil supply pipeline; control oil ports of each commutation linkage respectively connected to a control oil source by two proportional pressure reducing valves; two working oil ports of each commutation linkage respectively connected to an oil tank by two proportional relief valves; flow sensors and pressure sensors arranged on two working oil ports of each commutation linkage. A testing method includes: using the device for pressure loss tests, micro-motion characteristic tests and flow saturation resistant characteristic tests.

Load-sensitive multi-path valve testing device and testing method

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Jiangsu, China

Yan Dong