Chinese Academy of Sciences

Yaling An

Yan Li

Yi Shi

Mei Liu

Kun Xu

Jinghua Yan

Tianyi Zheng

Lianpan Dai

Fu Gao

The embodiments of the present disclosure relate to antigens of &#x3b2;-coronaviruses, preparation methods and uses thereof. The amino acid sequence of the antigen of the &#x3b2;-coronavirus includes an amino acid sequence arranged in a (A-B)-(A-B) pattern or an amino acid sequence arranged in a (A-B)-C-(A-B) pattern or an amino acid sequence arranged in a (A-B)-(A-B') pattern or an amino acid sequence arranged in a (A-B)-C-(A-B&#x2032;) pattern. The antigen of the &#x3b2;-coronavirus has a single-chain dimer structure. A single-chain dirtier expressed according to examples of the present disclosure is stable in content and has excellent immunogenicity as an antigen of a &#x3b2;-coronavirus, and a vaccine prepared by using the single-chain dimer as an antigen of a &#x3b2;-coronavirus can elicit high-titer neutralizing antibodies in mice.

Antigens of &#x3b2;-coronaviruses, preparation methods and uses thereof

Growing community of inventors

Beijing, China

Yaling An