Georgetown University

University of Oklahoma

Yali Kong

Milton L Brown

Jeffrey A Toretsky

Courtney W Houchen

Aykut Uren

Sripathi M Sureban

Parthasarathy Chandrakesan

Aykut Üren

Perrer N Tosso

Anatoly Dritschilo

Mira Jung

Shujie Hou

Jacqueline Smith

Christopher S Wilcox

Kan Wang

Milton Lang Brown

Aykut Ueren

Christopher Stuart Wilcox

Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I or a pharmaceutically acceptable salt thereof, wherein Z is —O— or —N(H)—.

Radiation mitigator and method of use thereof

Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I or a pharmaceutically acceptable salt thereof, wherein Z is &#x2014;O&#x2014; or &#x2014;N(H)&#x2014;.

Provided are methods useful for preventing and mitigating radiation injury, including acute radiation syndrome, comprising administering to a subject a therapeutically effective amount of a compound represented by formula I: 

A glutathione-cleavable prodrug is provided herein, as well as methods for its use in treating cancer, including triple negative breast cancer. The prodrug can be cleaved by glutathione under physiological conditions to generate a biologically active agent. The compound described herein is advantageous as the compound is fluorescent and can therefore be monitored within a subject.

Glutathione-cleavable prodrug and methods of use thereof

Peptides and compounds are provided that function as EWS-FLI1 protein inhibitors. The peptides and compounds have utility in the treatment of Ewing's sarcoma family of tumors. Also provided are methods of preparing the compounds and assays for identifying inhibitors of EWS-FLI1 protein.

Targeting of EWS-FLI1 as anti-tumor therapy

Compounds, compositions and methods relating to EWS-FLI1 protein inhibitors are provided. The compounds have utility in the treatment of cancers including the Ewing's sarcoma family of tumors.

Methods and compositions for treating Ewings sarcoma family of tumors

One aspect of the invention relates to compounds, compositions and methods for treating oxidative stress and/or hypertension. In certain embodiments, the invention relates to a mixture of tempol and an angiotensin receptor blocker (ARB) and the use of said mixture to treat oxidative stress and/or hypertension. In certain embodiments, the invention relates to a tempol/ARB adduct and the use of said adduct to treat oxidative stress and/or hypertension.

Treatment for oxidative stress and/or hypertension

Novel histone deacetylase inhibitors, including novel fluorescent histone deacetylase inhibitors, are described. Methods for making and using the same, e.g., to treat cancer, are provided.

Growing community of inventors

Centreville, VA, United States of America

Yali Kong