Immunopharmaceutics, Inc.

Yalamoori Venkatachalapathi

Ming Fai Chan

Chengde Wu

Adam Kois

Vitukudi Narayanaiyengar Balaji

Erik Joel Verner

Bore G Raju

Rosario Silvestre Castillo

N-(4-halo-isoxazolyl)sulfonamides and methods for modulating or altering the activity of the endothelin family of peptides are provided. In particular, N-(4-halo-3-isoxazolyl)sulfonamides and N-(4-halo-5-isoxazolyl)benzenesulfonamides and methods for inhibiting the binding of an endothelin peptide to an endothelin receptor or increasing the activity of endothelin peptides by contacting the receptor with a sulfonamide are provided. Methods for treating endothelin-mediated disorders by administering effective amounts of one or more of these sulfonamides or prodrugs thereof that inhibit or increase the activity of endothelin are also provided.

N-(4-halo-isoxazolyl)-sulfonamides and derivatives thereof that modulate

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San Diego, CA, United States of America

Yalamoori Venkatachalapathi