The University of Toledo

University of Toronto

Yakov Lapitsky

Youngwoo Seo

Kristopher Richardson

Molly S Shoichet

Yuanfei Wang

Yan Huang

Molly S Schoichet

Formulations having, as active agents, at least one quaternized polymeric microgel and at least one nonionic surfactant, methods of making, and methods of using are described.

Antibacterial surfactant/microgel formulations, methods of making and methods of using the same

Underwater adhesive materials, methods of making the same, and methods of using the same are described.

Ionically crosslinked polyelectrolytes as underwater adhesives as controlled release vehicles

Formulations having, as active agents, at least one quaternized polymeric microgel and at least one surfactant, methods of making, and methods of using are described.

In a first broad aspect, described herein is an antimicrobial formulation comprised of: at least one nonionic surfactant capable of providing colloidal stability to the formulation, and at least one quaternized polymeric microgel capable of being dispersed in the nonionic surfactant. The quaternized polymeric microgel is comprised of one or more of: chitosan oligomers or chitosan polymers. Further, the antimicrobial formulation is essentially free of cationic surfactants.

The incorporation of polymeric excipients into an injectable hydrogel matrix, for example, methyl cellulose in the case of a hydrogel matrix comprising hyaluronan and methylcellulose (HAMC) has been found to increase the solubility of sparingly soluble hydrophobic drugs and tune their rate of release. The hydrogel matrix may also include other sparingly soluble hydrophobic food or cosmetic agents.

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Toledo, OH, United States of America

Yakov Lapitsky