American Cyanamid Company

Yakov Gluzman, Deceased

Ian J Mohr

George A Ellestad

Bryan M O'Hara

Antonina A Nikitenko

John E Morin

James P LaRocque

Yuri E Raifeld

Wei-Dong Ding

Boris Mitsner

This invention provides triazine ring containing anionic compounds, pharmaceutical compositions containing these compounds and methods utilizing these compounds for treating viral infections, particularly infections by respiratory syncitial virus, the compounds having the general structure: ##STR1## and the pharmaceutically acceptable salt thereof.

Triazine containing anionic compounds useful as antiviral agents

Isolated tumoricidal herpetic viruses, in particular neurotrophic herpes viruses, T-lymphotrophic viruses, and B-lymphotrophic viruses, which are avirulent and capable of selectively replicating in and destroying neoplastic cells, and pharmaceutical compositions, vaccines, and methods of destroying neoplastic cells employing the isolated tumoricidal herpetic viruses are described. A method of isolating tumoricidal herpetic viruses by sequentially passaging attenuated, avirulent herpetic viruses on neoplastic cells which fail to support replication of the herpetic viruses and isolating the viruses which grow on the neoplastic cells is also described. Herpes simplex virus mutants having a genome from which the .gamma.34.5 genes have been deleted and which require at least one additional mutation to produce a non-neurovirulent herpes simplex virus which selectively replicates in and destroys neoplastic cells are also described.

Avirulent herpetic viruses useful as tumoricidal agents and vaccines

Growing community of inventors

Upper Saddle River, NJ, United States of America

Yakov Gluzman, Deceased