University of Washington

Koninklijke Philips Corporation N.v.

Koninklijke Philips N.v., a Corporporation Organized and Existing Under the Laws of Kingdom of the Netherlands

Yak-Nam Wang

Tatiana Khokhlova

Michael R Bailey

Vera Khokhlova

Adam D Maxwell

Wayne Kreider

George R Schade

Oleg A Sapozhnikov

Ari Partanen

Navid Farr

Lawrence A Crum

Thomas J Matula

Donghoon Lee

Wayne L Monsky

Julianna C Simon

An example method includes generating an acoustic ultrasound wave that is focused at a focal point. The method further includes sequentially directing the focal point upon distinct portions of an object to form respective shock waves at the distinct portions of the object. The method further includes, via the respective shock waves, causing the distinct portions of the object to boil and form respective vapor cavities. The method further includes causing substantially uniform ablation of a region of the object that comprises the distinct portions. The substantially uniform ablation is caused via interaction of the respective shock waves with the respective vapor cavities. An example ablation system and an example non-transitory computer-readable medium, both related to the example method, are also disclosed.

Boiling histotripsy methods and systems for uniform volumetric ablation of an object by high-intensity focused ultrasound waves with shocks

High intensity focused ultrasound systems for treating tissue are disclosed herein. A system of treating tissue in a patient in accordance with an embodiment of the present technology can include, for example, an ultrasound source having a focal region and configured to deliver high intensity focused ultrasound energy to a target site in tissue of the patient. The system can further include a controller operably coupled to the ultrasound source. The controller comprises a pulsing protocol for delivering the high intensity focused ultrasound energy with the ultrasound source to the target site. The controller is configured to cause the ultrasound source to pulse high intensity focused ultrasound waves to lyse cells in a volume of the tissue of the subject while preserving an extracellular matrix in the volume of the tissue exposed to the high intensity focused ultrasound waves.

High intensity focused ultrasound systems for treating tissue

Methods for treating an extravascular hematoma in a patient can include liquefying a first portion of the extravascular hematoma by applying a first series of focused acoustic pulses to the extravascular hematoma at a first frequency; and liquefying a second portion of the extravascular hematoma by applying a second series of focused acoustic pulses to the extravascular hematoma at a second frequency. Liquefied remains of the extravascular hematoma can be aspirated from the patient following liquefaction and disruption.

Histotripsy treatment of hematoma

Example embodiments of system and method for magnetic resonance imaging (MRI) techniques for planning, real-time monitoring, control, and post-treatment assessment of high intensity focused ultrasound (HIFU) mechanical fractionation of biological material are disclosed. An adapted form of HIFU, referred to as 'boiling histotripsy' (BH), can be used to cause mechanical fractionation of biological material. In contrast to conventional HIFU, which cause pure thermal ablation, BH can generate therapeutic destruction of biological tissue with a degree of control and precision that allows the process to be accurately measured and monitored in real-time as well as the outcome of the treatment can be evaluated using a variety of MRI techniques. Real-time monitoring also allow for real-time control of BH.

Method and system for MRI-based targeting, monitoring, and quantification of thermal and mechanical bioeffects in tissue induced by high intensity focused ultrasound

The present technology is directed to methods of soft tissue emulsification using a mechanism of ultrasonic atomization inside gas or vapor cavities, and associated systems and devices. In several embodiments, for example, a method of non-invasively treating tissue includes pulsing ultrasound energy from the ultrasound source toward the target site in tissue. The ultrasound source is configured to emit high intensity focused ultrasound (HIFU) waves. The target site comprises a pressure-release interface of a gas or vapor cavity located within the tissue. The method continues by generating shock waves in the tissue to induce a lesion in the tissue at the target site. The method additionally includes characterizing the lesion based on a degree of at least one of a mechanical or thermal ablation of the tissue.

Methods of soft tissue emulsification using a mechanism of ultrasonic atomization inside gas or vapor cavities and associated systems and devices

Growing community of inventors

Seattle, WA, United States of America

Yak-Nam Wang