Basf Aktiengesellschaft

Yajun Xu

Lee Daniel Arnold

Teresa Barlozzari

Paul Rafferty

Allyson Turner

Michael Hockley

Chemical compounds that are derivatives of indeno&lsqb;1,2-c&rsqb;pyrazole are inhibitors of tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell proliferation is a factor. Compounds of this invention also inhibit the induction of vascular hyperpermeability and the associated formation of edema, ascites, and exudates.

Indeno&lsqb;1,2-C&rsqb;pyrazole derivatives for inhibiting tyrosine kinase activity

Chemical compounds that are derivatives of indeno&lsqb;1,2-c&rsqb;-, naphtho&lsqb;1,2-c&rsqb;- and benzo&lsqb;6,7&rsqb;cyclohepta&lsqb;1,2-c&rsqb;pyrazole are inhibitors of tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in hyperproliferative, angiogenic or in vascular hyperpermeability processes. Thus, these chemical compounds can ameliorate disease states where tumor formation, metastasis, angiogenesis, vascular hyperpermeability or endothelial cell proliferation is a factor.

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Westborough, MA, United States of America

Yajun Xu