Pharmacopeia Inc.

Memory Pharmaceuticals Corporation

Msd Oss B.v.

Merck Sharp + Dohme B.v.

N.v. Organon

Yajing Rong

Michael H Ohlmeyer

Koc-Kan Ho

Nasrin Ansari

Irina Neagu

Andrew Laird Roughton

Ashok Tehim

Hans-Jurgen E Hess

Allen T Hopper

Michelle Lee Morris

David Jonathan Bennett

Ruiping Liu

Jui-Hsiang Chan

Andrew Stanley Edwards

Andrew John Cooke

David J Diller

Paul David Ratcliffe

Steven G Kultgen

Andrew Roughton

Andrew Cooke

Ronald Palin

Koc Kan Ho

The present invention relates to 1-(4-ureidobenzoyl)piperazine derivatives having the general Formula I (We bring to your attention that formula I is not provided on this electronic version as it is provided in the abstract of the paper copy) Wherein Ris (C)alkyl, (C)cycloalkyl or (C)cycloalkyl(C)alkyl, each of which may be substituted by hydroxy, cyano or halogen; Rrepresents 1 or 2 optional halogens; Ris (C)alkyl, (C)cycloalkyl or (C)cycloalkyl(C)alkyl, each of which may be substituted by one or more halogens; A represents a heteroaryl ring system comprising 1-3 heteroatoms selected from N, O and S, which ring system is 5- or 6-membered when X is C, and 5-membered when X is N; n is 1 or 2; or a pharmaceutically acceptable salt thereof; to pharmaceutical compositions comprising the same, and to the use of a these 1-(4-ureidobenzoyl)piperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholesterol and bile acids transport and metabolism. 

1-(4-ureidobenzoyl)piperazine derivatives

The present invention relates to N-benzyl,N'-arylcarbonylpiperazine derivatives having the general formula I to pharmaceutical compositions comprising the same, and to the use of a these N-benzyl,N&#x2032;-arylcarbonylpiperazine derivatives for the manufacture of a medicament for treating or preventing atherosclerosis and related disorders associated with cholesterol and bile acids transport and metabolism.

N-benzyl,N'-arylcarbonylpiperazine derivatives

The present invention relates to isoxazole-3-carboxamide derivative having the general Formula (I), or a pharmaceutically acceptable salt thereof, to pharmaceutical compositions comprising the same, as well as to the use of said isoxazole-3-carboxamide derivatives for the treatment of TRPV1 mediated disorders, such as acute and chronic pain disorders, acute and chronic neuropathic pain, acute and chronic inflammatory pain, respiratory diseases, and lower urinary tract disorders. 

5-phenyl-isoxazole-3-carboxamide derivatives as TRPV1 modulators

A chemical genus of purinones and 1H-imidazopyridinones, which are useful as PKC&#x3b8;. inhibitors, and their methods of use are disclosed. The genus is represented by the formula I:   A representative example is: 

Purinones and 1H-imidazopyridinones as PKC-theta inhibitors

PDE4 inhibition is achieved by novel compounds of the Formula I: wherein Rand Rare as defined herein.

Phosphodiesterase 4 inhibitors

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Monmouth Junction, NJ, United States of America

Yajing Rong