Inari Agriculture Technology, Inc.

Flagship Pioneering Innovations Vi, LLC

Flagship Pioneering Innovations V, Inc.

Inari Agriculture, Inc.

Flagship Pioneering Innovations Vii, LLC

Yajie Niu

Randall William Shultz

John Patrick Casey, Jr

Barry Andrew Martin

Maria Margarita D Unson

Michael Lee Nuccio

Michael Andreas Kock

Davide Sosso

Erik William Clement

Richard Bailey Flavell

Jennifer A Raji

Eva Konecna

Frank Anthony Skraly

Tomás Cermák

Hok Hei Tam

Hannah Pham

Maria Helena Christine Van Rooijen

Nataliya Vladimirovna Nukolova

Simon Schwizer

Daniel Garcia Cabanillas

Brian Prescott Fiske

Kristine Yu

Ignacio Martinez

Jonathan Dallas George Jones

Maier Steve Avendaño Amado

John P Casey

Piotr Stanislaw Kowalski

James Michael Kremer

Jayashree Kumar

Mehmet Ali Halac

Arjun Devang Khakhar

Tomáš Cermák

Elizabeth Jane Antonelli Dennis

Aditya Sushil Kumar Singh

Yumeng Hao

Fu Chyun Chu

Shankar Raj Pant

Disclosed herein are plant-modifying compositions including a plurality of plant messenger packs (PMPs) (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof), wherein the PMPs include a plant-modifying agent, and wherein the plant-modifying agent comprising the heterologous RNA. The compositions herein are useful in methods for modifying plants such as to increase plant fitness, wherein the increase in plant fitness comprising an increase in development, growth, yield, resistance to abiotic stressors, or resistance to biotic stressors.

Methods and compositions for the modification of plants

Synthetic endornaviral satellite RNA molecules and satellite particles containing the same are disclosed. The synthetic endornaviral satellite RNA molecules can include coding and/or non-coding cargo sequences, and are heritable through generations of plants. Also disclosed are methods of using the endornaviral satellite RNA molecules and satellite particles containing the same to change plant phenotypes, improve plant stress resistance, and improve plant pest and pathogen resistance.

Method for modifying plants with a recombinant RNA molecule

Disclosed herein are compositions and methods for effecting alterations at a defined location in the genome of a non-epidermal plant cell. Further disclosed are methods for providing plants having a modified phenotype or a modified genome.

Methods of genetically altering a whole plant seed

Disclosed herein are methods, and related bioreactors, for manufacturing plant messenger packs (PMPs), which can be formulated for use in a variety of agricultural and therapeutic methods.

Methods for manufacturing plant messenger packs

Systems, methods, and compositions for providing improvements in plant gene-editing efficiency are provided.

Methods for improved plant gene-editing

The disclosure relates to improvements in methods for efficient editing of two or more endogenous tomato genes by insertion of one or more single stranded DNA donor molecules that are not homologous to the insertion sites in the tomato genome.

Methods for efficient tomato genome editing

The disclosure relates to precise modifications in wheat plant genomes including the heterologous integration of nucleic acid sequences that include a regulatory element at a predetermined locus. Also provided are wheat cells, wheat plants, wheat seeds, and processed wheat products comprising the modified wheat genomes.

Heterologous integration of regulatory elements to alter gene expression in wheat cells and wheat plants

Disclosed herein are compositions and methods for effecting alterations at a defined location in the genome of a plant cell or plant protoplast. Further disclosed are methods using an RNA-guided nuclease to alter a target nucleotide sequence in a cell or protoplast of a plant; embodiments of such methods include treatments with chemical or physical reagents or treatment of the cell or protoplast with a specific thermal regime, such as a heat treatment.

Methods of altering a target nucleotide sequence with an RNA-guided nuclease and a single guide RNA

Disclosed herein are agricultural compositions comprising plant messenger packs (PMPs), methods for using the same, and methods and related bioreactors for manufacturing PMPs.

Agricultural compositions and related methods

The disclosure relates to improvements in methods for efficient editing of two or more endogenous soybean genes by insertion of one or more single stranded DNA donor molecules that are not homologous to the insertion sites in the soybean genome.

Methods for efficient soybean genome editing

Compounds and related reagents, systems, methods, and compositions for increasing the frequency of homology directed repair (HDR) of target genomic sites with genome editing molecules are provided.

Homology dependent repair genome editing

Plant cell cultures as well as related methods, systems, and compositions for increasing the frequency and efficiency of plant genome editing are provided. Various plant cell growth conditions and/or treatments where such increases in gene editing frequencies are obtained are disclosed.

Methods for increasing gene-editing frequencies in maize cells

Systems, methods, and compositions that provide for increased frequencies of plant gene editing in comparison to controls are provided herein. Also disclosed are compositions that provide for editing target genes in plant cells. Systems for modification of a plant genome and/or target plant gene are provided. Methods for modifying a plant cell genome or a target plant gene in a plant cell genome are also provided. Compositions, plant cell cultures, and/or reaction mixtures comprising plant cells, certain agents, and gene editing molecules are also provided herein.

Plant gene editing systems, methods, and compositions

The invention relates to novel plants, seeds and compositions, as well as improvements to plant breeding and methods for creating modifications in plant genomes.

Method of creating a plurality of targeted insertions in a plant cell

The invention relates to novel maize plants, seeds and compositions, as well as improvements to maize plant breeding and methods for creating modifications in maize plant genomes.

Growing community of inventors

Lexington, MA, United States of America

Yajie Niu