Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Yahui Guo

Fei Liu

Hongjian Wang

Yanlong Liu

Ming Zhang

Zhongyuan Hu

Huihui Zhang

Lei Xing

Wenyuan Qian

Provided is a salt of an Syk inhibitor and a crystalline form thereof, and more specifically, provided are 5-fluoro-1-methyl-3-((5-(4-(oxetan-3-yl)piperazine-1)-yl)pyridin-2-yl)amino)-6-(1H-pyrazol-3-yl)quinoline-2(1H)-ketamine hydrochloride, a crystalline form thereof, a preparation method therefor, a pharmaceutical composition thereof and a use thereof. The hydrochloride of the compound represented by formula I and the crystalline form thereof have good salt-forming properties, high stability and low hygroscopicity, have advantages in terms of physical properties, safety and metabolic stability, and have value in prepared medicines.

Salt of Syk inhibitor and crystalline form thereof

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Lianyungang, China

Yahui Guo