Nanjing Legend Biotech Co., Ltd.

Huawei Technologies Co., Limited

Tencent Technology (shenzhen) Company Limited

Yafeng Zhang

Chuan-Chu Chou

Shu Wu

Shuai Yang

Xi Yang

Shujian Yuan

Shuxiang Wang

Zhongdao Li

Fangliang Zhang

Zhenyu Liu

Fei Sun

Yunlei Fu

Provided are constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes PD-1. Also provided are methods of making and using these constructs.

Single-domain antibodies and variants thereof against PD-1

The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes PD-L1. Also provided are methods of making and using these constructs.

Single-domain antibodies and variants thereof against PD-L1

Novel antibodies, such as single domain antibodies (sdAbs), or antigen-binding fragments thereof that specifically bind a transferrin are described. Compositions, methods and systems for increasing the half-life of a target protein in a serum using an antibody or fragment thereof against a transferrin are also described.

Compositions and methods using a single-domain antibody binding transferrin and protein A for increasing protein half-life in serum

The present application provides constructs comprising a single-domain antibody (sdAb) moiety that specifically recognizes cytotoxic T-lymphocyte-associated protein 4 (CTLA-4). Also provided are methods of making and using these constructs.

Single-domain antibodies and variants thereof against CTLA-4

Disclosed herein are multispecific, such as bispecific, antigen binding proteins comprising a first antigen binding domain comprising a heavy chain variable domain and a light chain variable domain, and a second antigen binding domain comprising a single-domain antibody. Pharmaceutical compositions comprising the multispecific antigen binding proteins, kits and methods of use thereof are further provided.

Multispecific antigen binding proteins and methods of use thereof

The present application provides an IPv6 address tracing method, apparatus, and system, where the method includes: receiving a to-be-traced target IPv6 address; selecting, in a longest match manner, IPv6 address information that matches the target IPv6 address, where the IPv6 address information includes an IPv6 address or IPv6 prefix information; and acquiring a user identifier corresponding to the IPv6 address information. The present application implements IPv6 address tracing.

IPV6 address tracing method, apparatus, and system

A system for processing a sound signal includes a mobile terminal that obtains a series of sound waveform values in a first location. The mobile terminal obtains a sound waveform value within a valid sound waveform value range from the series of sound waveform values and transmits the sound waveform value to a computing device in a second location, so that the computing device performs a logic operation corresponding to the sound waveform value. A mobile terminal can transmit a sound waveform value to a computing device at a location remote from the mobile terminal to perform a logic operation corresponding to the sound waveform value, and total system performance, including the computing device and the mobile terminal, is improved.

Method, mobile terminal and system for processing sound signal

Embodiments of the present application provide a charging method, a charging device, a charging system, and an authentication device. According to the technical solutions provided in the embodiments of the present application, when the available service volume of the user is not enough at the time close to the tariff switch point, the operation of forcing a user to go offline may be performed selectively, depending on the specific situation. Therefore, the operation of forcing a user to go offline can meet requirements of increasingly complicated charging policies of the operator.

Charging method, charging device, charging system, and authentication device

A charging method, an authentication method, a charging device, and an authentication device. The charging method includes receiving a service unit request sent by an access device, calculating a granted service unit according to a current tariff, determining a reporting time point according to a tariff switch point and returning a service unit answer to the access device; and receiving a used service unit reported by the access device at the reporting time point, calculating a remaining service unit based on the granted service unit and the used service unit instructing the access device to perform a forcible offline operation. The technical solutions provided by the embodiments of the present disclosure may effectively reduce an occurrence probability of a user account overdraft, thereby reducing a loss caused by the user account overdraft to an operator.

Charging method, authentication method, charging device, and authentication device

A charging method, an authentication method, a charging device, and an authentication device. The charging method includes: receiving a service unit request sent by an access device, calculating a granted service unit according to a current tariff, determining a reporting time point according to a tariff switch point and returning a service unit answer to the access device; and receiving a used service unit reported by the access device at the reporting time point, calculating a remaining service unit based on the granted service unit and the used service unit instructing the access device to perform a forcible offline operation. The technical solutions provided by the embodiments of the present invention may effectively reduce an occurrence probability of a user account overdraft, thereby reducing a loss caused by the user account overdraft to an operator.

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Nanjing, China

Yafeng Zhang