Chinese Academy of Sciences

Shanghai Xudong Haipu Pharmaceutical Co., Ltd

Yafeng Zhan

Zheng Wang

Xiaolin Chen

Pengfei Gao

Yi Liang

Yike Yang

Provided are a method and system for individualized prediction of mental illness on the basis of brain function map monkey-human cross-species migration, and a method for determining a mental illness prediction model. The method for determining a mental illness prediction model comprises the steps: (a) data acquisition; (b) preprocessing; (c) brain region selection; (d) feature construction; (e) feature screening; and (f) modeling prediction. The method and system are non-invasive and have high accuracy, high sensitivity, good specificity, and are convenient to popularize.

Method and system for individualized prediction of mental illness on basis of brain function map monkey-human cross-species migration

Disclosed is a method for refining 5-fluorouracil, comprising the following steps: dissolving 5-fluorouracil in an organic solvent, preferably DMSO, heating and stirring until dissolved; naturally cooling the filtrate until a crystal is precipitated; filtering, washing a filter cake using a polar solvent, and draining and drying under reduced pressure. By using the new refining method, the content of impurities in 5-fluorouracil may be reduced to less than 0.01%, the product purity is more than 99.98%, and the refining yield is higher than 70%. In addition, the refining method of the present invention has a simple process, convenient operation, low production costs, high product purity, a stable process, and is suitable for industrial production.

Composition of 5-fluorouracil and refining method therefor

Growing community of inventors

Shanghai, China

Yafeng Zhan