Santen Pharmaceutical Co., Ltd.

Yaeko Osumi

Takahiro Honda

Ken-ichi Fujimura

Masashi Niwa

Shin-ichi Kohno

Maki Tokai

A method of treating pain or pruritis comprising administering to a patient in need thereof a pharmaceutically effective amount of a &#x3ba; opioid receptor agonist of the formula wherein R is an alkyl having an amino group as a substituent; and Ris acyl.

Method for treating pain or pruritis by administering &#x3ba;-opioid receptor agonist comprising 2-phenylbenzothiazoline derivative

A compound or a salt thereof having the following formula wherein Ris acyl, Ris hydrogen, halogen, unsubstituted alkyl or alkyl substituted by halogen; Ris halogen or alkoxy; Ris cycloalkyl, unsubstituted alkyl or alkyl substituted by cycloalkyl, aryl or hydroxyl or an ester thereof or alkoxy; Ris hydroxyl or an ester thereof, alkoxy or alkoxyalkyl; or Rand Rare bonded with each other to form a pyrrolidine ring substituted by hydroxyl or an ester thereof, alkoxy or alkoxyalkyl; Ris hydroxyl or an ester thereof, alkoxy, alkoxyalkoxy, alkoxyalkoxyalkoxy, mercapto or alkylthio; and Aand A, are the same or different, and are alkylene, provided that (i) when Rand Rare bonded to each other to form the pyrrolidine ring substituted by hydroxyl or an ester thereof, Ris halogen; (ii) when Rand Rare bonded to each other to form the pyrrolidine ring substituted by alkoxyalkyl, Ris hydrogen; (iii) when Ris hydroxyl or an ester thereof, Ris isopropyl.

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Osaka, Japan

Yaeko Osumi