The University of Queensland

Seattle Children's Hospital

Seattle Biomedical Research Institute

Yadveer Grewal

Gerard A Cangelosi

Matt Trau

Muhammad J A Shiddiky

Muhammad JA Shiddiky

The present disclosure relates to biofragment compositions that comprise bioparticle fragments and at least one heterologous antigen-binding molecule. In some embodiments, the biofragment is typically derived from a larger, intact bioparticle that express the at least one heterologous antigen-binding molecule at the surface, and the biofragment has increased solubility to facilitate assays for antigen detection. The disclosure also relates the related methods of using and making the biofragment compositions, as well as systems and devices implementing the biofragment compositions. In some embodiments, the related methods, systems and devices do not require additional detection reagents, such as animal derived detection antibodies.

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Logan City, Australia

Yadveer Grewal