Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

The General Hospital Corporation

Hadasit Medical Research Services and Development Ltd.

Other

Fraunhofer-Gesellschaft Zur Foerderung Der Angewandten Forschung E.V.

Colibri Photonics Gmbh

Hurel Corporation

Technion Research & Development Foundation Limited

Yaakov Nahmias

Martin L Yarmush

Shimon Mizrahi

Elchanan Fried

Itai Hayut

Yoav Mintz

Gahl Levy

Yoav Kan-Tor

Amnon Buxboim

Eric Novik

Piyush Koria

Robert Freedman

Ariel Shrem

Or Hazan

Ran Eliaz

Yonathan Avraham Demma

Michal Zimerman

Yishai Avior

Sebastian Prill

Ziv Menshes

Magnus Jaeger

Danny Bavli

Tommy Weiss-Sadan

Elmar Schmälzlin

Ory Ramon

Tal Hasin

Aharon Oren

Eva Abramov

Yoel Goldstein

Nir Salzman

Eyal Shimoni

Isaiah J Kopelman

A system for growing cells comprising a bioreactor chamber for growing the cells, a delivery system delivering a perfusion solution to the bioreactor chamber for perfusion of the perfusion solution through the cells, a dialysis system having a dialyzer, a dialysate for performing a dialysis and a filter for reducing ammonia content in said dialysate, and a controller that circulates the perfusion solution through the dialyzer and the dialysate through the filter.

Systems and methods for growing cells in vitro

Provided are in-vitro methods and devices for sustaining a synchronized circadian rhythm in cells of a cell culture by exposing the cells to a continuous flow of medium and to at least two stimuli provided in an oscillating manner with a periodicity of 24±4 hours, wherein a first stimulus and a second stimulus of said at least two stimuli are distinct, wherein said first stimulus is provided in a first time period and reaches a first peak in a first peak time period, and wherein a second stimulus is provided in a second time period and reaches a second peak in a second peak time period, and wherein an interval between end of time period of said first peak and beginning of said time period of said second peak is at least about 2 hours.

Method to reproduce circadian rhythms on a microfluidic chip

Device for accessing a pericardial space of a subject in need thereof, the device including a tubular member having an atraumatic distal end and a thread formed on, and at least partially around, the outer surface of the tubular member, proximally to the distal end; wherein the thread is configured to cut, puncture and/or penetrate a pericardium.

Device, system and method for pericardial access

A guided tracheal intubation system using an autonomous modulated light source, outputting modulated illumination at a constant level, and externally applied to the subject's larynx region. An optical imaging system receives a video stream from within the subject's throat, including modulated illumination from the subject's trachea. A display control system performs signal processing on the modulated content of the images, and outputs frames of those images in which the intensity level of illumination from the trachea can be controlled without any need to change the illumination output from the modulated light source. The light source has no connection with the rest of the system, and need contain no more than a battery, a power supply circuit and a light source. It can therefore be of low cost and can be made disposable, such as in the form of an adhesive patch applied to the subject's neck.

Guided endotracheal intubation system

A method of measuring a Jugular Pulse property, comprising: Optionally, the method comprises cooling tissue at said imaged location adjacent said vein using said device. In some embodiments, the device is designed to mount at a same neck axial position when disconnected and reattached and the system provided is designed to enforce the same body position to allow for comparable repeat measurements.

Jugular venous assessment

Provided are methods of increasing metabolic maturation of an immature hepatocyte, by contacting an immature hepatocyte which expresses alpha-fetoprotein (AFP) and albumin with an effective amount of a fatty acid or a small molecule selected from the group consisting of: an amphipathic carboxylic acid, Thiazolidinedione (TZD), WY-14643 (Pirinixic Acid), GW409544, GW6471, Leukotriene B4, GW 7647, Perfluorooctanesulfonic Acid, Perfluorooctanoic Acid, CP-775146, CP-865520, UNII-999KY5ZIGB, and Gemfibrozil. Also provided are isolated hepatocytes and uses thereof.

Methods of inducing metabolic maturation of human pluripotent stem cells&#x2014; derived hepatocytes

Systems, kits and methods for non-invasive, long-term, real-time monitoring of one or more physiological parameters of a cell, including but not limited to oxygen uptake, are provided.

Method and system for continous monitoring of toxicity

Compositions and methods described herein provide a cell culture system in which cells are in high metabolic states from the onset of the culture. Combinations of various cell culture components disclosed and employed herein allow cells to be in high metabolic states useful for drug testing immediately after the start of cell culture.

Compositions and methods of functionally enhanced in vitro cell culture system

The invention is based on the discovery of a potent growth factor delivery system by creating a fusion polypeptide that includes two portions: (i) keratinocyte growth factor protein, and (ii) an elastin-like peptide. This chimera can be administered directly to a wound site, accelerating recovery.

Elastin based growth factor delivery platform for wound healing and regeneration

Growing community of inventors

Rishon Lezion, Israel

Yaakov Nahmias