Industrial Technology Research Institute

Ya-Ping Lai

Min-Yuan Chou

Chuan-Chuan Huang

Hsiu-Chuan Li

Li-Tsen Lin

Mei-Wei Lin

Wei-Chun Chiu

Ssu-Yuan Wu

Chin-Pen Lai

Chung-Yuan Sun

Antibodies and antigen-binding fragments that bind to TIGIT are disclosed. The disclosure further relates to methods and compositions for use in treating an immune-related disease (e.g., a cancer or an infection or infectious disease) by administering a composition disclosed herein.

Anti-TIGIT antibodies and methods of use

The present invention relates to a method for producing multivalent Fab fragments. In particular, the invention relates to a method for the generation of trimeric Fab fragments by co-expression of a gene construct comprising a heavy chain portion of a Fab fragment and an in-frame fused collagen-like peptide, and a gene construct consisting of a light chain portion of an IgG in mammalian cells. Uses of molecules generated using the method of the invention are also described.

Method for producing a multivalent fab fragment with collagen-like peptide

The embodiments of the invention relate to compositions, methods, and kits comprising a fusion protein. The fusion proteins of the embodiments include monomer polypeptides which in one embodiment have at least a binding domain, an optional hinge region, a collagen-like domain and the Fc domain of a human IgG.

TNF receptor Fc fusion proteins and in vivo methods of use

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Zhudong, Taiwan

Ya-Ping Lai