The United States of America, As Represented by the Secretary, Department of Health and Human Services

The University of Arizona

Ya-Ming Xu

James Brislin McMahon

Curtis J Henrich

Alan David Brooks

Thomas Joseph Sayers

Poonam Tewary

Leslie Gunatilaka

Kithsiri Wijeratne

Disclosed is a method of enhancing the response of cancer cells in a mammal to treatment with an apoptosis inducing ligand, which method comprises contacting the cancer cells with an apoptosis inducing ligand in conjunction with an effective amount of a compound of the formula: (I), wherein R-Rare as described herein. Also disclosed is a method of inducing apoptosis in cancer cells in a mammal, comprising contacting the cancer cells with the compound described herein and also contacting the cancer cells with an apoptosis inducing ligand, whereby apoptosis is induced in the cancer cells. 

Method of sensitizing cancer cells to the cytotoxic effects of apoptosis inducing ligands in cancer treatment

Growing community of inventors

Tucson, AZ, United States of America

Ya-Ming Xu