Industrial Technology Research Institute

Ya-Ling Chiu

Pei-Shin Jiang

Ping-Fu Cheng

Tseng-Huang Liu

Maggie Lu

Po-Yen Lin

Felice Cheng

Shih-Ta Chen

Yu-Wen Lo

Wen-Hsuan Chiang

Kang-Li Wang

A nucleic acid-drug complex is provided in the present disclosure, which includes a nucleic acid sequence of an anti-PD-L1 aptamer and a CpG oligonucleotide sequence capable of activating TLR9, in which the CpG oligonucleotide sequence consists of a first fragment and a second fragment, and the nucleic acid sequence of the anti-PD-L1 aptamer is inserted between the first fragment and the second fragment.

Nucleic acid-drug complex and use thereof

A hydrogel composition is provided. The hydrogel composition includes polyglutamic acid (PGA) containing maleimide groups, and polyethylene glycol (PEG) containing terminal thiol groups, wherein the hydrogel composition has a pH value ranging from 4.0 to 6.5. A drug delivery system is also provided. The drug delivery system includes the above-mentioned hydrogel composition, and a pharmaceutically active ingredient encapsulated in the hydrogel composition.

Hydrogel compositions and drug delivery systems comprising the same

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Hsinchu, Taiwan

Ya-Ling Chiu