Medtronic Vascular, Inc.

Medtronic, Inc.

Ya Guo

Kishore Udipi

Peiwen Cheng

Kshitija P Garde

David Clarke

Joseph Berglund

Benjamin Wong

Wei Wang

Laura McKinley

Paul Devereux

Yogesh Darekar

Tracey Tien

Joshua Dudney

Karl Olney

Luke Lehmann

Raymond Ryan

Joshua J Dwork

James Mitchell

Adam Shipley

Susheel Deshmukh

Justin Peterson

Jeffrey W Allen

Hubert K Yeung

John P Shanahan

Nate Glucklich

Mingfei Chen

Christopher W Storment

Robert T Taepke

Jill Mendelson

Abby Schlichting

Abby S Pandya

Laura Mckinley

Padraigh Jennings

Stephen Montgomery

Karina Doyle

Gerry Kearns

Constantino Fiuza

Abhijeet Misra

Rajesh Prasannavenkatesan

James A Wright

Jill P Mendelson

Susheel R Deshmukh

A 'dry' packaging in which a prosthetic heart valve is packaged within a container with hydrogel that can be provided in many forms. Certain embodiments include hydrogel that is preloaded with glycerol or the like. The hydrogel regulates the humidity within the container through a diffusion-driven mechanism if a gradient of humidity between the inside and the outside of the hydrogel exists. Humidity regulation is important to prevent the tissue of the valve structure from drying out. When the partially-hydrated hydrogel is present within container, which is saturated with air of a predefined humidity, the water molecules from the air will be absorbed by the hydrogel if the air humidity is high (i.e. when the thermodynamics favor hydrogel hydration) or vice versa. Various embodiments are configured to also house at least a portion of a delivery device for delivering the prosthetic heart valve.

Packaging for dry tissue prosthetic heart valve

Methods and apparatus are disclosed for filling a therapeutic substance or drug within a hollow wire that forms a stent. The stent is placed within a chamber housing a fluid drug formulation. During filling, the chamber is maintained at or near the vapor-liquid equilibrium of the solvent of the fluid drug formulation. To fill the stent, a portion of the stent is placed into contact with the fluid drug formulation until a lumenal space defined by the hollow wire is filled with the fluid drug formulation via capillary action. After filling is complete, the stent is retracted such that the stent is no longer in contact with the fluid drug formulation. The solvent vapor pressure within the chamber is reduced to evaporate a solvent of the fluid drug formulation. A wicking means may control transfer of the fluid drug formulation into the stent.

Apparatus and methods for filling a drug eluting medical device via capillary action

A fixation device configured to anchor an implantable medical device within a patient includes a temporary biodegradable fixation mechanism configured to secure the device after implantation until the temporary fixation mechanism biodegrades and a chronic fixation mechanism configured to promote tissue growth that secures the device to tissue of the patient before the temporary fixation mechanism biodegrades.

Medical device fixation

Implantable medical devices having a metallic surface coated with a bioabsorbable primer polymer layer under a bioabsorbable drug polymer layer. Thus, in addition to the degradation of the drug polymer layer, there is degradation of the primer layer. The underlying metallic framework may or may not degrade depending on whether bioabsorbable or biostable metals are chosen.

Implantable medical devices having bioabsorbable primer polymer coatings

A stent includes a bioabsorbable metal, a hydrothermal conversion film covering the bioabsorbable metal, and a coating covering the hydrothermal conversion film. A method for manufacturing a stent includes forming a stent body comprising a bioabsorbable metal, forming a hydrothermal conversion film over surfaces of the stent body, and coating the hydrothermal conversion film with an overcoat.

Bioabsorbable stent with hydrothermal conversion film and coating

A percutaneous stented valve delivery device including an inner shaft, a sheath, and a delivery capsule. The sheath slidably receives the inner shaft. A capsule proximal zone is attached to the sheath. A capsule distal zone is configured to transition between normal and flared states. A diameter of the distal zone is greater in the flared state, and the capsule includes a shape memory component that naturally assumes the normal state. The device is operable to perform a reversible partial deployment procedure in which a portion of the prosthesis is exposed distal the capsule and allowed to radially expand. Subsequently, with distal advancement of the capsule, the distal zone transitions to the flared state and imparts a collapsing force onto the prosthesis, causing the prosthesis to radially collapse and become recaptured within the delivery capsule. The capsule can include a laser cut tube encapsulated by a polymer.

Stented transcatheter prosthetic heart valve delivery system and method

Disclosed herein are implantable medical devices comprising controlled release biodegradable block copolymers or coated with controlled release block copolymers and at least one drug releasable from the block copolymer. The controlled release block copolymers comprise least two blocks selected from the group consisting of polyesters, polyethers, and polyurethanes.

Block biodegradable copolymers for medical devices

Disclosed herein are implantable medical devices having controlled release biodegradable polymer coatings thereon wherein the polymer is formed from ring opening of &#x3b3;-butyrolactone and at least one additional monomer selected from the group consisting of trimethylene carbonate, lactide, polyethylene glycol, glycolide, the monomers formed from ring opening of &#x3b5;-caprolactone, 4-tert-butyl caprolactone, and N-acetyl caprolactone, and combinations thereof, and at least one drug releasable from the biodegradable polymer. Also disclosed are implantable medical devices form of the biodegradable polymers and processes for forming the polymers.

Degradable polymers incorporating gamma-butyrolactone

Growing community of inventors

Santa Rosa, CA, United States of America

Ya Guo