Columbia University

Y Lawrence Yao

David Jonathan Brenner

Gerhard Randers-Pehrson

Nabil Simaan

Guy Garty

Jian Zhang

Alessio Salerno

Aparajita Dutta

W Louis Cleveland

Oleksandra V Lyulko

Gen Satoh

Xi Long

Anubha Bhatla

Paul Di Pietro

A method, article of manufacture, and system for joining different materials is described. In a principal embodiment, two articles, for example different metals, are placed in proximity to one another with an interfacial area. One article is heated using a laser that is scanned across from a point remote from the interface to a point at or just short of the interface. In embodiments, the interfacial bond region is characterized by a homogenous mixed phase region with very low to substantially no brittle intermetallics.

Methods, devices, systems for joining materials and resulting articles

A method of identifying and localizing objects belonging to one of three or more classes, includes deriving vectors, each being mapped to one of the objects, where each of the vectors is an element of an N-dimensional space. The method includes training an ensemble of binary classifiers with a CISS technique, using an ECOC technique. For each object corresponding to a class, the method includes calculating a probability that the associated vector belongs to a particular class, using an ECOC probability estimation technique. In another embodiment, increased detection accuracy is achieved by using images obtained with different contrast methods. A nonlinear dimensional reduction technique, Kernel PCA, was employed to extract features from the multi-contrast composite image. The Kernel PCA preprocessing shows improvements over traditional linear PCA preprocessing possibly due to its ability to capture high-order, nonlinear correlations in the high dimensional image space.

Methods and systems for identifying and localizing objects based on features of the objects that are mapped to a vector

Systems and methods for high-throughput radiation biodosimetry are disclosed herein. In some embodiments, a high-throughput methods of analyzing a population for radiation exposure can include, in various possible sequences: marking a first capillary designed to retain a first sample from the population with a first identifier; transporting a plurality of samples to a biodosimetry system; inputting the samples into the biodosimetry system; centrifuging the plurality of samples including the first sample wherein each sample can be retained in a capillary and the first sample can be retained in the first capillary; transferring the plurality of capillaries including the first capillary from the centrifuge to a cutting device using a robotic device; cutting the first capillary; reading the first identifier; transferring at least one portion of the first sample from the first capillary to a well in an array, wherein the array can include one or more filters in a multi-well plate; correlating the first identifier to a location of the array that includes the at least one portion of the first sample; one or more cycles of biological processing, which can include addition of a reagent and/or incubation of a selected temperature such as, for example, 37&#xb0; C., 4&#xb0; C., room temperature, and the like; sealing the array; positioning the array adjacent to an imaging element; focusing the imaging element; capturing an image of the first sample in the array; and analyzing the image to determine whether the first sample indicates a level of radiation exposure exceeding a predetermined threshold.

Systems and methods for high-throughput radiation biodosimetry

Systems and methods for robotic transport are disclosed herein. In some embodiments, robotic systems for transporting biological samples include: a plurality of capillary vessels, in which each capillary vessel can contain a biological sample from a population; a receptacle that can contain the plurality of capillary vessels; a centrifuge; a first robotic device that can transport the receptacle between an input module and the centrifuge; a second robotic device that can transport the receptacle between the centrifuge and a sample harvest location; a cutting device that can cut each of the plurality of capillary vessels; a multi-well plate having a plurality of wells arranged in an array; and a third robotic device that can transfer at least one portion of each of the plurality of biological samples from each of the plurality of capillary vessels to a corresponding well in the array.

Systems and methods for robotic transport

A system and method for stabilizing the cutting front temperature of a laser beam on a workpiece in order to improve the quality of the laser beam cut. The technique and system models the temperature of a virtual grid of nodes on the workpiece's surface and determines the effect of the laser beam on each node's temperature including the creation of the kerf. An optimization technique is then performed on the results from temperature model which creates a power data profile to indicate the correct level of power which the laser should be operated for every point on the laser cut. The technique and system is especially useful when boundary, turns or holes are required where the cutting conditions change creating excessive heat accumulation.

Simulator and optimizer of laser cutting process

Growing community of inventors

New York, NY, United States of America

Y Lawrence Yao