Southern Research Institute

The United States of America

The United States Government

Y Fulmer Shealy

C Allen O'Dell

Charles A Krauth

William M Shannon

Joe D Clayton

The present invention is directed to retinyl ethers, derivatives and analogues and their use in inhibiting breast carcinogenesis or breast cancer cell growth.

Retinyl ethers, derivatives and analogues and inhibition of breast carcinogenesis

There are disclosed 3-substituted and 3,3-disubstituted all-trans-4-oxoretinoic acids and 3-substituted and 3,3-disubstituted 13-cis-4-oxoretinoic acids and their lower alkyl esters.

3-substituted and 3,3-disubstituted 4-oxoretinoic acids and their esters

There are disclosed compounds represented by Formulas I-III: ##STR1## wherein X is an azido group or an amino group and R is hydrogen or an acyl group. These compounds are useful for the treatment of viral infections and/or as intermediates in the production of compounds which are useful in the treatment of viral infections.

Carbocyclic analogues of amino and azido thymidines

There are disclosed carbocyclic analogs of 2-amino-6-substituted-purine ribofuranosides and 2-amino-6-substituted-8-azapurine ribofuranosides. These compounds are useful in the treatment of viral infections.

Carbocyclic analogs of purine ribofuranosides

Compounds of the formula: ##STR1## wherein R is methyl or other lower alkyl group; X and X' individually are hydrogen, lower alkyl, aryl, or halogen; and R' is a 2-haloethyl group or other halogenated lower alkyl group are useful in the treatment of neoplastic diseases.

(Alkylsulfonyl)methanesulfonates as anticancer agents

There are disclosed compounds having the formula: ##STR1## wherein R is a group having the formula --C.tbd.CSi(CH.sub.3).sub.3, --C.tbd.CH, --CH.dbd.CH.sub.2, --CH.sub.2 CH.sub.2 Si(CH.sub.3).sub.3 or --CH.sub.2 X; X is bromo, chloro or iodo; and R' is hydrogen or an acyl group, with the proviso that when R is --CH.sub.2 X, R' is an acyl group. Certain of these compounds are active in inhibiting the replication of DNA viruses. Other of these compounds are useful as intermediates in the production of compounds which are active in inhibiting the replication of DNA viruses.

Carbocyclic analogues of thymine nucleosides

Compounds of the formula: ##STR1## wherein R is methyl or other lower alkyl group; X and X' individually are hydrogen or lower alkyl; and R' is a 2-haloethyl group or other halogenated lower alkyl group are useful in the treatment of neoplastic diseases.

There are disclosed carbocyclic analogs of 2-amino-6-substituted-purine 2'-deoxyribofuranosides and 2-amino-6-substituted-8-azapurine 2'-deoxyribofuranosides. The compounds are useful in the treatment of viral infections.

Carbocyclic analogs of purine 2'-deoxyribofuranosides

There is provided a method for the treatment of viral infections by treating a host animal with a pharmaceutically effective amount of a carbocyclic analog of a nucleoside represented by Formula I: ##STR1## wherein X is chlorine, bromine, iodine, a lower alkyl group or an amino group of the formula --NHR.sup.2 wherein R.sup.2 is a lower alkyl group; and R and R' can be the same or different members selected from the group consisting of hydrogen, an alkanoyl group or an aroyl group.

Carbocyclic analogs of uracil nucleosides as antiviral agents

Novel compounds are disclosed which are carbocyclic analogs of cytosine nucleosides in which the pentose moiety of the nucleoside is replaced by a cyclopentane ring. The novel compounds exhibit antiviral activity, and certain of them also exhibit antineoplastic activity against the L 1210 mouse leukemia test system.

Growing community of inventors

Birmingham, AL, United States of America

Y Fulmer Shealy