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Genetronics, Inc.

Xuyang Li

Robert J Schwartz

Eric M Eastman

Jeff Nordstrom

Ruxandra Draghia-Akli

The invention concerns making and evaluating synthetic regulatory regions for controlling gene expression. The invention features a method for identifying transcription factor binding sites and a method for evaluating the regulatory functions of synthetic regulatory regions.

Synthetic cell-or tissue-specific transcriptional regulatory regions

Vectors which establish controlled expression of recombinant GHRH genes within tissues at certain levels. The vector includes a 5&prime; flanking region which includes necessary sequences for expression of a nucleic acid cassette, a 3&prime; flanking region including a 3&prime;UTR and/or 3&prime;NCR, and a linker which connects the 5&prime; flanking region to a nucleic acid sequence. The linker has a position for inserting a nucleic acid cassette. The linker does not contain the coding sequence of a gene that the linker is naturally associated with. The 3&prime; flanking region is 3&prime; to the position for inserting the nucleic acid cassette.

Growth hormone releasing hormone expression system and methods of use, including use in animals

Method for the identification of synthetic cell- or tissue- specific transcriptional regulatory regions

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Houston, TX, United States of America

Xuyang Li