Novartis Ag

Alcon, Inc.

Dsm IP Assets B.v.

Xuwei Jiang

Walter R Laredo

Douglas Schlueter

Ali E Akinay

Ahmad Robert Hadba

Robert S Ward

Jian Liu

David Jinkerson

Vincent Nguyen

Thomas A Callaghan

Yuan Tian

Jingbo Liu

Frank Chang

Troy Vernon Holland

Keith R McCrea

Ryan DeSousa

James Parakka

Shanger Wang

Ananth V Iyer

Ryan Desousa

Scott Curtin

Anfeng Wang

The present disclosure provides an intralocular-lens (IOL) or ophthalmic device including an optic and at least one haptic, at least a portion of which is formed from a photoresponsive shape memory polymer network, such as a polydomain azo liquid crystalline polymer network (PD-LCN). The present disclosure further provides systems and methods for adjusting the position of such an IOL or other ophthalmic device using polarized laser radiation.

In-situ adjustable intraocular lens

The present disclosure provides an intraocular lens (IOL) or ophthalmic device including an optic and at least one haptic, at least a portion of which is formed from a photoresponsive shape memory polymer network, such as a polydomain azo liquid crystalline polymer network (PD-LCN). The present disclosure further provides systems and methods for adjusting the position of such an IOL or other ophthalmic device using polarized laser radiation.

The present invention provides novel intraocular lens compositions comprising a hydroxyl functional acrylic monomerand have a high Abbe number, minimal glistenings, and suitable mechanical properties for small incision delivery.

Intraocular lens compositions

Soft hydrophobic acrylic materials with improved resistance to fluid diffusion and suitable mechanical properties that allow deformation upon application of force are disclosed. The acrylic materials are particularly suitable for use in fluid-based accommodating intraocular lenses and comprises combination of a perfluoro-substituted alkyl (meth)acrylate and an alkyl (meth)acrylate, and a cross-linking agent.

Soft hydrophobic acrylic materials

The present invention provides novel intraocular lens compositions comprising a hydroxyl functional acrylic monomer and have a high Abbe number, minimal glistenings, and suitable mechanical properties for small incision delivery.

Described herein are UV-absorbing vinylic monomers and their uses in preparing UV-absorbing contact lenses capable of blocking ultra-violet ('UV') radiation and violet radiation with wavelengths from 380 nm to 440 nm, thereby protecting eyes to some extent from damages caused by UV radiation and potentially from violet radiation.

UV/visible-absorbing vinylic monomers and uses thereof

Intraocular lens materials are disclosed. They are soft and very deformable and have a high refractive index, and a high glistening resistance in fully hydrated state. They are particularly suitable for making wet-packed intraocular lenses (IOLs) which can be delivered through sub 2.0 mm incisions.

Wet-pack intraocular lens materials with high refractive index

Acrylate-acrylamide copolymers are disclosed. They are rigid and glassy in dry state at room temperature (from about 23&#xb0; C. to about 28&#xb0; C.), but are soft and very deformable and have a high refractive index, a high glistening resistance and a low aging-related surface light scattering in fully hydrated state. They are particularly suitable for making wet-packed intraocular lenses (IOLs) which can be delivered through sub 2.0 mm incisions.

Low-water content acrylate-acrylamide copolymers for ophthalmic devices

Hydrophobic acrylate-acrylamide copolymers for ophthalmic devices

Disclosed are improved ophthalmic and otorhinolaryngological device materials and devices formed therewith. The device materials are soft, high refractive index styrenic device materials that are used to form the ophthalmic or otorhinolaryngological devices, particularly ophthalmic implants (e.g., intraocular lenses).

Styrenic ophthalmic and otorhinolaryngological materials and devices formed therewith

High refractive index acrylic device materials with reduced glistenings are disclosed. The device materials are particularly suitable for use as ophthalmic or otorhhinolaryngological device materials and comprises a poly(phenyl ether)-containing monomer and/or a poly(phenyl ether)-containing cross-linking agent.

Soft acrylic materials with high refractive index and minimized glistening

Polymer surface modification method comprising the steps of first forming a surface of primary reactive end groups tethered to the polymer chain ends during fabrication of an article, and then modifying the reactive surface with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, or polymers to attain specific surface properties. Alternatively, a multifunctional coupling agent can be used to couple the primary reactive group to a second reactive group capable of reacting with a functional group associated with bio-active molecules, hydrophilic and hydrophobic monomers, oligomers, and polymers to attain specific surface properties. The invention involves bringing reactive endgroups to the surface with surface active spacer attached to the polymer chain end. The surface active spacer allows the migration and enrichment of reactive end groups to the surface during fabrication. The invention provides medical devices having a bio-interface with anti-thrombogenic properties, lubricity, selective adsorption, and antimicrobial properties.

Surface modification of polymers via surface active and reactive end groups

Amphiphilic biomimetic phosphorylcholine-containing silicone compounds for use in both topical and internal applications as components in biomedical devices. The silicone compounds, which include zwitterionic phosphorylcholine groups, may be polymerizable or non-polymerizable. Specific examples of applications include use as active functional components in ophthalmic lenses, ophthalmic lens care solutions, liquid bandages, wound dressings, and lubricious and anti-thrombogenic coatings.

Phosphorylcholine-based amphiphilic silicones for medical applications

Disclosed are low-tack, hydrophobic, high refractive index, acrylic materials. These materials, especially useful as intraocular lens materials, contain one or more aryl acrylic hydrophobic monomers as principal device-forming monomers, a tack-reducing block copolymer additive and a glistening-reducing additive. In addition to their use as intraocular lens materials, the present materials are also suitable for use in other implantable ophthalmic devices.

Growing community of inventors

Arlington, TX, United States of America

Xuwei Jiang