Ludwig Institute for Cancer Research Limited

Licentia, Ltd.

Flanders Interuniversity Institute for Biotechnology

Xuri Li

Ulf Eriksson

Karin Aase

Annica Ponten

Kari Alitalo

Carl-Henrik Heldin

Peter Carmeliet

Marko Uutela

Milos Pekny

Arne Oestman

Hong Li

Samuel Gebre-Medhin

Christer Betsholtz

Desire Collen

Gabriel Von Euler

VEGF-B is shown to be needed for cardiac muscle revascularization after heart infarction, and methods of promoting or stimulating vascular development, e.g. angiogenesis and/or arteriogenesis, particularly in ischemic mammals, are disclosed.

Stimulation of vascularization with VEGF-B-186

PDGF-D, a new member of the PDGF/VEGF family of polypeptide growth factors, is described, as well as nucleotide sequences encoding, methods for producing, pharmaceutical compositions containing this new growth factor, and its antibodies and other antagonists. Also disclosed are transfected and transformed host cells expressing PDGF-D, and uses thereof in medical and diagnostic applications.

Platelet-derived growth factor D, DNA coding therefor, and uses thereof

Non-human transgenic animals overexpressing PDGF-C and cells thereof have been created. The transgenic animals contain a nucleotide sequence that encodes for platelet derived growth factor C (PDGF-C) or an analog thereof, or a functional fragment of PDGF-C or analog thereof. These animals are useful for studying disease states characterized by overexpression of PDGF-C, as well as useful for evaluating therapies intended to treat such diseases.

Non-human transgenic animals expressing platelet-derived growth factor C (PDGF-C) and uses thereof

A method and kit for detecting the presence of tumor cells in an animal by detecting expression of VEGF-B , determining an increased expression of VEGF-B , or by determining an increased expression of VEGF-B relative to expression of VEGF-B . The kit comprises a receptacle adapted to receive a sample and a means for detecting expression of VEGF-B from the sample. Also, a method for screening for anti-tumor agents.

Methods for detecting for the presence of tumor cells and for screening for anti-tumor agents

Transgenic animals containing recombinant DNA with modified nucleotide sequence from the vascular endothelial growth factor B (VEGF-B) gene, cells and methods for producing such animals, and methods of using them to assay substances for VEGF-B-like activity.

Transgenic animal with recombinant vascular endothelial growth factor B (VEGF-B DNA) and uses thereof

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Stockholm, Sweden

Xuri Li