Ngm Biopharmaceuticals, Inc.

Xunshan Ding

Zhonghao Liu

Yan Wang

Wenwu Zhai

Yiyuan Yin

Chun Chu

The present disclosure provides binding agents, such as antibodies, that specifically bind Angiopoietin-like protein 8 (ANGPTL8), including human ANGPTL8, and methods of their use.

Methods of lowering triglyceride levels with an ANGPTL8-binding antibody or antigen-binding fragment thereof

ANGPTL8-binding agents and methods of use thereof

Methods and compositions for reducing one or more of triglyceride levels, total cholesterol levels and LDL cholesterol levels in a subject are provided. The methods include administering a fragment of ANGPTL8 to a subject having or at risk of developing elevated triglyceride levels, elevated total cholesterol levels and/or elevated LDL cholesterol levels.

Angiopoietin-like protein 8 polypeptide fragments and compositions thereof

Methods for treatment of conditions associated with elevated triglycerides with an ANGPTL8 polypeptide fragment

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Millbrae, CA, United States of America

Xunshan Ding