Shanghai First People's Hospital

Other

University of Massachusetts

Xu, Xun

Xu, Yan

Xun Xu

Hui Zhao

Yan Xu

Ying Zheng

Guangping Gao

Phillip D Zamore

Yi Xu

Yi Lu

Phillip Tai

Qiao Sun

Qiang Zheng

Lili Wang

The disclosure relates, in some aspects, to compositions and methods for treating corneal disease (e.g., corneal neovascularization. In some embodiments, the disclosure relates to rAAV-mediated delivery of an cornea-associated transgene to a subject. In some embodiments, the rAAV transduces the corneal tissue of a subject.

Anti-angiogenic miRNA therapeutics for inhibiting corneal neovascularization

The present invention provides a polypeptide that is rich in leucine and used for preventing and restraining inflammation, and an application of same. The present invention further provides a method for preparing the polypeptide and a pharmaceutical composition containing the polypeptide. The advantage of the polypeptide comprises: small molecular weight, so as to permeate various eye tissue barriers; high water solubility, so as to have high dissolubility in neutral tears, aqueous humor and vitreous humor; and simple synthesis, so as to have a low preparation cost.

Small molecule polypeptide for preventing and restraining inflammation and application of same

Disclosed are a low molecular polypeptide for preventing and treating inflammation, a preparation method and the use thereof and a pharmaceutical composition containing the polypeptide, wherein the polypeptide can penetrate the eye tissue barrier, can maintain a high concentration in neutral tears, aqueous humour and vitreous humour, and can be used to treat inflammation.

Low molecular polypeptide for preventing and treating inflammation and use thereof

Small molecule polypeptide for inhibiting inflammation

Provided is a polypeptide having angiogenesis inhibiting activity. The polypeptide is derived from Placenta Growth Factor-1. Also provided are a derivative polypeptide of the polypeptide, a preparation method for polypeptide, and a pharmaceutical composition containing the polypeptide.

Polypeptides inhibiting neovascularization and uses thereof

Angiogenesis-inhibiting peptide and application thereof

Provided is a low molecular polypeptide that can inhibit angiogenesis consisting of amino acid sequence YRGKKA, which is same to one portion sequence in apolipoprotein (a) Kringle V. Also provided are pharmaceutical composition and the uses for preventing or treating diseases relating to angiogenesis.

Polypeptide inhibiting angiogenesis and application thereof

Growing community of inventors

Shanghai, China

Xun Xu