The Hong Kong Polytechnic University

The Royal Institution for the Advancement of Learning / Mcgill University

Mcgill University

Xun He

Tak-Hang Chan

Masad Jose Damha

Robert Alexander Donga

Weishi Miao

The present invention relates to ionic liquids for use in chemical applications and capable of serving the dual function of solvent and liquid support. The ionic liquid lends itself to a method of synthesizing oligomers selected from the group consisting of oligopeptides, oligosaccharides and oligonucleotides, comprising contacting a first monomer unit with an ionic liquid at reaction conditions to provide an ionic liquid bound monomer unit; and contacting the ionic liquid bound monomer unit with at least one further monomer unit at reaction conditions to provide an ionic liquid bound oligomer comprising from 2 to 30 monomer units. The method lends itself to large scale manufacture of oligopeptides, oligosaccharides and oligonucleotides.

Ionic liquid supported synthesis

The present disclosure relates to structurally defined imidazolium-type ionic oligomers of the formula: wherein n is an integer ranging from 1 to 20; A is N or m is an integer ranging from 1 to 5; X is selected from the group consisting of Br, OTf, CFCO, CHCO, BF, PF, NTf, F, Cl and I; and R is selected from the group consisting of hydrogen and Calkyl. The imidazolium-type ionic oligomers lend themselves as soluble/solid supports for biopolymer synthesis.

Imidazolium-type ionic oligomers

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Hockessin, DE, United States of America

Xun He