Chia Tai Tianqing Pharmaceutical Group Co., Ltd.

Xujing Tang

Xiquan Zhang

Hongjiang Xu

Fei Liu

Shanchun Wang

Yanlong Liu

Weiwei Feng

Bin Wang

Jinan Wang

Jianqing Zhang

Ling Yang

Wei Shi

Yizhong Zhu

Hongmei Gu

Song Tang

Hongying Zhang

Yiyan Yao

Yang Li

Limin Liu

Quandeng Nie

Yubing Wang

Disclosed is a trifluoromethyl-substituted sulfonamide BCL-2-selective inhibitor, in particular disclosed are a compound of formula I, a stereoisomer or a pharmaceutically acceptable salt thereof, a preparation method therefor, and a pharmaceutical composition thereof. Also disclosed are the uses of said compound and of a pharmaceutical composition comprising same for treating anti-apoptotic BCL-2-related diseases, such as cancer.

Trifluoromethyl-substituted sulfonamide as BCL-2-selective inhibitor

Disclosed is a methyl- and trifluoromethyl-containing disubstituted sulfonamide selective BCL-2 inhibitor; specifically disclosed are a compound of formula I, a stereoisomer or pharmaceutically acceptable salt of same, a preparation method therefor, and a pharmaceutical composition comprising the compound. Also disclosed are uses of the compound and of the pharmaceutical composition comprising the compound in treating anti-apoptotic protein BCL-2-related diseases such as cancer.

Methyl- and trifluoromethyl-containing disubstituted sulfonamide selective BCL-2 inhibitor

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Lianyungang, China

Xujing Tang