Precigen, Inc.

Mbp Titan LLC

Xuezhi Li

James Kealey

Kevin Lee Dietzel

Louis Clark

Xinhua Zhao

Lily Yuin Chao

Mark Anton Held

Na Trinh

Matthias Helmut Schmalisch

Grayson Wawrzyn

Jeffrey Orth

Christopher Cheyney Farwell

Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as isobutanol are disclosed. For example, genetically modified methanotrophs that are capable of generating isobutanol at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.

Methods and microorganisms for the fermentation of methane to multi-carbon compounds

Methods of genetically modifying microorganisms using advanced genome editing are disclosed. Methods of modifying the genome of these microorganisms for point mutations, deletions, and DNA insertions are also disclosed. Further, inhibiting expression of genes without manipulating the genome of the microorganism is disclosed. In some cases, the microorganism can be a methylotroph, e.g., a methanotroph.

Advanced genome editing

Genetically modified microorganisms that have the ability to convert carbon substrates into multicarbon products. Methods of making these genetically modified microorganisms and methods of using them. Vectors encoding enzymes for use in converting carbon substrates into multicarbon products.

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Hayward, CA, United States of America

Xuezhi Li