Chinese Academy of Sciences

First Hospital, Jinlin University

Xuesi Chen

Kai Zhang

Zhen Zhang

Zhaohui Tang

Haiyang Yu

Wantong Song

Mingqiang Li

Xiuli Zuang

Xiabin Jing

Tongjun Liu

Shaohui Liu

Xiaoyi Xu

Xinchao Bian

Youzhu Li

Chaoliang He

Hui Ren

The present invention provides a polyethylene glycol derivative comprising a repeat unit having the structure of Formula (I) and a terminal group having the structure of Formula (II). The polyethylene glycol derivative provided by the present invention has good biocompatibility, due to the repeat unit having the structure of Formula (I); and can react with various groups such as amino, (acyl)hydrazino, and aminooxy with a fast reaction rate under mild reaction conditions, due to the o-phthalaldehyde terminal group having the structure of Formula (II). The polyethylene glycol derivative provided by the present invention is mixed with polyethylene glycol having an amino-containing terminal group in an aqueous medium, to rapidly form a chemically cross-linked hydrogel material. The hydrogel material has mild preparation conditions, fast gel-forming speed, high mechanical strength, and good stability. This polyethylene glycol hydrogel can be applied as drug sustained-release carrier, tissue engineering scaffold, etc. in the field of biomedical materials.

Polyethylene glycol derivative, preparation method thereof, and polyethylene glycol hydrogel capable of producing a rapid crosslinking reaction

A CDDP complex is formed by complexation of CDDP and a polymer having a structure of Formula (I). The CDDP complex has good biocompatibility and is degradable. A side chain of the polymer is grafted with polyethylene glycol, which gives the CDDP complex good dissolvability. When dissolved in an aqueous medium, the CDDP is protected by a hydrophilic polyethylene glycol chain segment and a hydrophobic amino acid chain segment, which can effectively avoid a sudden release of the CDDP due to the influence of the blood circulation system after intravenous injection, thus improving the stability of the CDDP complex. A carboxyl group contained in the CDDP complex has pH value sensitivity and tends to be deprotonated in a low pH environment, which is advantageous for promoting the release of a drug, and improving the efficiency of the drug.

Cisplatin complex and preparation method thereof

A biodegradable common bile duct stent and the method for preparing thereof are provided. The stent is made of biodegradable polymeric material with incorporation of X-ray opaque components. The stent adapts to the anatomical shape of the CBD or it can be sutured together with the wall of the bile duct. After placing the stent in the duct, it maintains its position and does not slip. The circular tube of the stent being suitably sized and having multiple ring-shaped protruding rims at the outer wall and/or with larynx structure, leakage and outflow of the bile are thereby prevented. It can be manufactured by a conventional injection-molding or an extrusion-blowing technique. In surgical operation on the bile duct, the stent can replace the T-tube which is conventionally used to support the duct and guide bile drainage. It can reduce the time required for surgical operation and treatment, reduce possible complications and can be degraded and eliminated as the incision heals and the CBD regains its normal functions.

Biodegradable common bile duct stent and the method for preparing thereof

Growing community of inventors

Changchun, China

Xuesi Chen