Mayo Foundation for Medical Education and Research

Xueqian Yin

Edward B Leof

Jeong-Han Kang

Mark C Wilkes

Mahefatiana Andrianifahanana

Claire E Repellin

This document provides polypeptide inhibitors of Smad3 polypeptide activities. For example, methods and materials for using polypeptides (e.g., polypeptides designed to include both a cell penetrating amino acid sequence and an amino acid segment of a SH3 domain of a SNX9 polypeptide) to inhibit one or more Smad3 polypeptide activities are provided. This document also provides methods and materials for using RNA interference to treat a disease (e.g., a fibrotic disease) in a mammal (e.g., a human).

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Xueqian Yin