Amgen Inc.

Chemocentryx, Inc.

Xuemei Wang

Julio Cesar Medina

Feng Xu

Liusheng Zhu

Jiwen Liu

Alan X Huang

Tassie Collins

Hossen Mahmud

Jonathan B Houze

Thomas J Schall

Wang Shen

Matthew Irvine Brown

Michael G Johnson

Daniel J Dairaghi

Yingcai Wang

Sarah Lively

An-Rong Li

Brian E McMaster

Qingge Xu

Matthew Brown

Sarah E Lively

Compounds, compositions and methods that are useful in the treatment of inflammatory and immune-related diseases and conditions are provided herein. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.

Compounds and methods useful for treating asthma and allergic inflammation

Compounds and compositions are provided that bind to the CCR4 chemokine receptor and which are useful for treating diseases associated with CCR4 activity, such as contact hypersensitivity.

Modulation of CCR4 function

Compounds, compositions and methods are provided that are useful in the treatment of chemokine receptor-mediated conditions and diseases. In particular, the invention provides compounds which modulate CCR4 function or a CCR4-mediated response. The subject compounds and compositions are useful for the treatment or prevention of inflammatory conditions and diseases.

CCR4 antagonists

The present invention provides compounds, compositions and methods for the inhibition or treatment of conditions or disorders modulated by the STAT transcription factors, particularly STAT4 and STAT6. Additionally, the compounds are useful for the diagnosis of conditions dependent on STAT signaling.

STAT modulators

Growing community of inventors

San Mateo, CA, United States of America

Xuemei Wang