Pfizer Corporation

Pfizer Products Inc.

Other

Pharmacia & Upjohn Company

Pah USA 15 LLC

Xuemei Cao

Michael G Sheppard

Jay Gregory Calvert

Chichi Huang

Siao-Kun Wan Welch

Michael K O'Hara

Gabriele M Zybarth

Gabriele Zybarth

The present invention provides safe vaccines and methods of preparing such vaccines. The vaccines of the present invention contain at least two live mutant viruses of the same family or nucleic acid molecules encoding such viruses, wherein each of the two viruses or the encoding nucleic acids contains a mutation that confers a desirable phenotype and the mutations in the viruses reside in the same genomic site such that the mutant viruses cannot recombine with each other to eliminate the mutations.

Safe mutant viral vaccines

The present invention provides safe vaccines and methods of preparing such vaccines. The vaccines of the present invention contain at least two live mutant viruses of the same family or nucleic acid molecules encoding such viruses, wherein each of the two viruses or the encoding nucleic adds contains a mutation that confers a desirable phenotype and the mutations in the viruses reside in the same genomic site such that the mutant viruses cannot recombine with each other to eliminate the mutations.

The present invention provides genetically engineered type I/type II hybrid BVDV viruses. The hybrid viruses, as well as the hybrid viral genome, can be used in immunogenic compositions and vaccines for protecting cattle from BVDV infection.

Generation of type I/type II hybrid form of bovine viral diarrhea virus for use as vaccine

The present invention is directed to a method of producing attenuated forms of bovine viral diarrhea (BVD) virus by mutating the Nprotease gene. The invention includes the attenuated viruses made by this method, antibodies generated using these viruses, and vaccines that can be used for immunizing cattle.

Attenuated forms of bovine viral diarrhea virus

The present invention is directed to a method of producing attenuated forms of bovine viral diarrhea (BVD) virus by mutating the N protease gene. The invention includes the attenuated viruses made by the method, antibodies generated using these viruses, and vaccines that can be used for immunizing cattle.

The present invention is directed to a method of producing attenuated forms of bovine viral diarrhea (BVD) virus by mutating the N protease gene. The invention includes the attenuated viruses made by this method, antibodies generated using these viruses, and vaccines that can be used for immunizing cattle.

The present invention is directed to a method of producing attenuated forms of bovine viral diarrhea (BVD) virus by mutating the N,protease gene. The invention includes the attenuated viruses made by this method, antibodies generated using these viruses, and vaccines that can be used for immunizing cattle.

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East Lyme, CT, United States of America

Xuemei Cao