Remegen Co., Ltd.

Remegen, Ltd.

Xuejing Yao

Jianmin Fang

Jing Jiang

Guiping Qi

Wenlong Sun

Changjiang Huang

Ling Wang

Hui Ye

Qiaoyu Xu

Xuejing Luan

Hongwen Li

Fangfang Sun

Li Wang

Zhuanglin Li

Qianjing Bao

Haohua Jie

Shizhong Zhai

The present disclosure relates to a method for detecting DTPA content in ADC by LC-MS/MS. The samples are derivatized with Feunder a weak alkaline derivatization condition, and a weak alkaline mobile phase is used, without need for addition of ion-pair reagents. This method has the characteristics of high efficiency, high stability and strong durability, and can well make up for the defects of few DTPA detection methods and complicated operations in the prior art.

Method for detecting DTPA content in ADC by LC-MS/MS

The present disclosure relates to a method for detecting TCEP content in ADC by LC-MS/MS. The ADC samples are derivatized by Ellman reaction, and then the TCEP content is measured by LC-MS/MS. This method can exclude the interference caused by the substances that may react with Ellman in complex ADC samples, which provides with no need for sample pretreatment, and with strong specificity.

Method for detecting TCEP content in ADC by LC-MS/MS

The present invention relates to a bifunctional angiogenesis inhibitor, which has VEGF inhibitory activity and FGF inhibitory activity, and can inhibit VEGF and FGF dual factors-induced or high glucose-induced cell proliferation, cell migration, and/or lumen formation. The present invention also relates to the use of the bifunctional angiogenesis inhibitor in inhibiting retinal angiogenesis, such as diabetic retinopathy, age-related macular degeneration and the like.

Bifunctional angiogenesis inhibitor and use thereof

Disclosed are an anti-HER2 antibody and conjugate of the anti-HER2 antibody and small molecule medicine. Also disclosed are uses of the antibody and conjugate thereof in preparing medicine for treating tumor.

Anti-HER2 antibody and conjugate thereof

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Yantai, China

Xuejing Yao