Bristol-myers Squibb Compnay

Xuejie Yang

Yuping Qiu

Makonen Belema

Lawrence B Snyder

Michael H Serrano-Wu

Denis R St Laurent

Fukang Yang

Ramesh Kakarla

Omar D Lopez

Jeffrey Lee Romine

Van N Nguyen

Jason T Goodrich

Francis Beaulieu

Fred Christopher Zusi

Nicholas A Meanwell

William John Pitts

Alain Martel

Anne Marinier

Yunhui Zhang

Min Gao

Amy Mae Bunker

Carl Ouellet

John E Leet

Stephan Roy

Julie A Lemm

Donald R O'Boyle, Ii

Carl Quellet

Christopher Zusi

Ramesh Kakaria

Donald R Ii O'BOYLE

The present disclosure is generally directed to antiviral compounds, and more specifically directed to compounds which can inhibit the function of the NS5A protein encoded by Hepatitis C virus (HCV), compositions comprising such compounds, and methods for inhibiting the function of the NS5A protein.

Hepatitis C virus inhibitors

Compounds having the structure of formula I are described. The compounds can inhibit hepatitis C virus (HCV) replication, and in particular can inhibit the function of the HCV NS5A protein.

Inhibitors of HCV replication

The present invention provides for pyrazolopurine-based tricyclic compounds having the formula (I), wherein R, R, R, R, Rand Rare as described herein. The present invention further provides pharmaceutical compositions comprising such compounds, as well as the use of such compounds for treating inflammatory and immune diseases.

Pyrazolopurine-based tricyclic compounds and pharmaceutical compositions comprising same

Compounds of formula (I), or pharmaceutically-acceptable salts thereof, are useful in treating inflammatory and immune diseases and disorders,

Amino-substituted tetracyclic compounds useful as anti-inflammatory agents and pharmaceutical compositions comprising same

Compounds having the formula (I),and pharmaceutically-acceptable salts, hydrates and prodrugs thereof, are useful as anti-inflammatory agents, in which R, R, and Rare hydrogen, halogen, alkyl, or perfluoroalkyl; Ris an optionally substituted alkyl or cycloalkyl group; X is a linker; A is an aryl, heteroaryl, heterocycle, cycloalkyl, or is absent; and Ris a substituent on A as defined in the specification.

Thiophene-based tricyclic compounds and pharmaceutical compositions comprising same

Growing community of inventors

Wallingford, CT, United States of America

Xuejie Yang