Ohr Pharmaceutical Inc.

Genaera Corporation

Xuehai Zhang

William Alvin Kinney

Harold Meckler

Roy Clifford Levitt

Ronald Stanley Michalak

Michael McLane

Meena N Rao

Roy C Levitt, Jr

Nancy Lee

Eric Chellquist

Kyle Armbruster

Charles W Gilbert

Mary Doubleday

Michael Mclane

Ronald Michalak

Charles Gilbert

Steven Jones

Michel Bulliard

The invention relates to select squalamine salts, methods of their synthesis, their therapeutic use and their advantages relating to manufacturing, product stability and toxicity. More specifically, this application is directed to various forms of the dilactate salt of squalamine and their utility in inhibiting neovascularization and endothelial cell proliferation.

Polymorphic and amorphous salt forms of squalamine dilactate

An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective sulfonation of a fused ring system. The fused ring system base can be, for example, a steroid ring base. The aminosterol compounds are effective as, among others, antibiotics, antiangiogenic agents and NHE3 inhibitors.

Regioselective and stereoselective oxidation of fused ring systems useful for the preparation of aminosterols

An efficient method for the synthesis of aminosterol compounds such as squalamine and compound 1436 is described. A method of the invention provides for regioselective oxidation and regioselective sulfonation of a fused ring system. The fused ring base can be, for example, a steroid ring base. The aminosterol compounds are effective as, for example, antibiotics, antiangiogenic agents and NHE3 inhibitors.

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East Norriton, PA, United States of America

Xuehai Zhang