Zhucheng Haotian Pharm Co., Ltd.

Shanghai Ri Xin Biotechnology Co., Ltd.

Shanghai Raising Pharmaceutical Co., Ltd.

Cocrystal Technology (Jiaxing) Co., Ltd

Xuefeng Mei

Jianrong Wang

Liping Zhu

Huan Yun Zhang

Chunjiu Zhong

Yinhua He

Yu Wang

Lei Li

Jianxin Gu

Linlin Sun

Ying Huang

Liye Lu

Huan Zhang

Bingqing Zhu

Yuhang Jiang

The present invention is directed to crystalline polymorphs of benfotiamine, its methods of preparation and its use thereof. Five crystalline polymorphs of benfotiamine are designated as crystalline forms A, B, C, D and E, and may be distinguished by their respective patterns of X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), infrared spectroscopy (IR), raman spectroscopy, moreover by their diverse preparing process. The crystalline polymorphs of the present invention are useful as they act in treating Vitamin B1 deficiency, metabolic disorders, mental illness and disorders, diabetes complications, neurodegerative diseases. Further the present invention is a process for preparing and transforming diverse crystalline form of benfotiamine through different synthesis routes and varied solvents and combinations. The crystalline polymorphs of the present invention are basically pure. The present invention not only provides new crystalline forms of benfotiamine, but also provides its new solvates, especially hydrates.

Crystalline polymorphs of benfotiamine, process for preparation and its use thereof

The present invention relates to a stevioside M crystal form, a preparation method therefor and a use thereof, and specifically, relates to a naturally extracted high-intensity sweetener, i.e., a stevioside M crystal form A, the preparation method therefor and the user thereof. By means of comprehensive characterization of the new crystal form, the new crystal form is found to have advantages such as a high degree of crystallinity, good stability, and low hygroscopicity, and is applicable to a more comprehensive field of application. The preparation method in the present invention is simple and easy to operate, has high selectivity and good reproducibility, and can stably obtain the target crystal form.

Stevioside M crystal form, preparation method therefor and use thereof

Provided are crystalline form A of rebaudioside D, and a preparation method and application therefor. In X-ray powder diffraction analysis measured using Cu-K&#x3b1; rays and with 2&#x3b8; being expressed in degrees, crystalline form A of rebaudioside D has significant characteristic diffraction peaks at least at 4.53, 6.38, 12.76, 13.52, 17.48, 17.96, 20.07 and 22.63. The preparation method is a suspension method, a solvent evaporation method or a cooling method. The preparation method has a simple process, and is convenient to operate. A rebaudioside D crystalline form A product has a good degree of crystallinity, good water solubility, and high chemical stability.

Crystalline form A of rebaudioside D, and preparation method and application therefor

The present invention relates to the technical field of chemical drugs and crystal form processes, and to a pyrroloquinoline quinine B crystal form and a preparation method therefor. The present invention comprehensively characterizes the pyrroloquinoline quinine B crystal form by virtue of means such as X-ray powder diffraction analysis, thermo-gravimetric analysis, and differential scanning calorimetry analysis so as to find the fact that the pyrroloquinoline quinine B crystal form is high in crystallinity and low in hygroscopicity, and a regular crystal form can be formed, thereby facilitating process treatment and improvement of physical and chemical properties of a medicine, and improving the patent medicine performance. The preparation method for the pyrroloquinoline quinone B crystal form provided in the present invention is simple, easy to control, and high in reproducibility.

Pyrroloquinoline quinone B crystal form and preparation method therefor

The present invention provides pyrroloquinoline quinone lithium salt crystal and a preparation method and application thereof. Characteristic absorption peaks appear when the diffraction angles are 6.222&#xb1;0.2&#xb0;, 7.379&#xb1;0.2&#xb0;, 7.941&#xb1;0.2&#xb0;, 23.631&#xb1;0.2&#xb0;, 24.044&#xb1;0.2&#xb0;, 25.497&#xb1;0.2&#xb0;, 27.541&#xb1;0.2&#xb0;, 30.736&#xb1;0.2&#xb0;, and 32.306&#xb1;0.2&#xb0; degrees in a powder X-ray diffraction pattern of the pyrroloquinoline quinine lithium salt crystal. The maximum value of thermal absorption of the pyrroloquinoline quinine lithium salt crystal appears between 90&#xb0; C. and 96&#xb0; C. through differential scanning calorimetry. Peaks appear when infrared spectroscopy of the pyrroloquinoline quinine lithium salt crystal is at 3396.03 cm, 1652.70 cm, 1604.48 cm, 1500.35 cm, 1355.71 cm, 1243.86 cm, 1147.44 cm, 808.03 cm, 761.74 cm, and 570.83 cm. The pyrroloquinoline quinine lithium salt polymorphism can be applied to preparation of medicines for curing memory damage.

Pyrroloquinoline quinone lithium salt crystal and preparation method and application thereof

The present invention relates to crystalline forms of pyrroloquinoline quinone disodium salt. The present invention provides crystalline Form A and crystalline Form B of pyrroloquinoline quinone disodium salt, and the methods and uses for the preparation thereof. The X-ray powder diffraction patterns of crystalline Form A and crystalline Form B are as shown by FIG.and FIG., respectively. The crystalline forms of the present invention have low moisture absorption and high stability, as well as excellent use and storage performances.

Crystalline forms of pyrroloquinoline quinone disodium salt

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Xuefeng Mei