Chengdu Origin Biotechnology Limited Company

Xuechao Wang

Peng He

Haiyan Li

Hai Zhao

Pei Huang

Guangxin Dong

Ta Deng

Shuang Chen

The present application provides a borate ester compound suitable for being used as a proteasome inhibitor, a preparation method and use thereof, and the compound has the following structure wherein, R, Ris asymmetric substituent in para-position, and Rand Rare both selected from the group consisting of halogen; and when Ris F, Ris not Cl; when Ris Cl, Ris not Br or F; and when Ris Br, Ris not Cl; X, Xis selected from the group consisting of hydroxyl, or Xand Xtogether form a substituted or unsubstituted 4 to 10 membered ring containing 1 to 4 heteroatoms being selected from the group consisting of O, N and S.

Borate-based drug and use thereof

A borate compound serving as a proteasome inhibitor, a preparation method for the borate compound and uses thereof.

Borate compound, and synthesis method therefor and uses thereof

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Sichuan, China

Xuechao Wang