St. Jude Medical, Cardiology Division, Inc.

Other

St. Jude Medical, Inc.

Xue Mei Li

Peter Nicholas Braido

Ping Peter Xie

Thomas M Benson

Sounthara (ott) Khouengboua

Yousef F Alkhatib

Michael P Meyer

Brian Joseph Perszyk

Sounthara Khouengboua

Guofu Huang

Mike Meyer

Kerry Y Xie

Thomas Mark Benson

A prosthetic heart valve includes a stent having a collapsed condition and an expanded condition. The stent includes a plurality of cells, each cell being formed by a plurality of struts, and a plurality of commissure features. The heart valve further includes a valve assembly secured to the stent and including a cuff and a plurality of leaflets, each leaflet being attached to adjacent commissure features and to the stent struts and/or the cuff.

Valve leaflet attachment in collapsible prosthetic valves

A prosthetic heart valve includes a collapsible stent and a valve assembly disposed within the stent. A first cuff is disposed adjacent the stent. A filler is annularly disposed about the stent radially outward of the first cuff and radially outward of the stent. The filler has a first circumferential layer with a first inner wall, a first outer wall, and a plurality of first ribs connecting the first inner wall to the first outer wall. The filler has an expanded condition in which the first inner wall is spaced a first distance from the first outer wall in a radial direction transverse to the longitudinal direction of the stent, and a collapsed condition in which the first inner wall is spaced a second distance from the first outer wall in the radial direction, the first distance being greater than the second distance.

Self-expandable filler for mitigating paravalvular leak

A stent (') for a prosthetic heart valve includes a body having an inflow end () and an outflow end (), and an anchoring section () adjacent the inflow end. The anchoring section may include structure () that extends radially outwardly from the body when the stent is in an expanded condition. The stent may include a transition section () between the body and the anchoring section, the transition section in the expanded condition of the stent having a diameter that is smaller than the diameters of the body and the anchoring section. When implanted into a native valve annulus, such as the mitral valve annulus, the anchoring section may help the stent resist migrating away from the native valve annulus.

Stents with anchoring sections

A prosthetic heart valve may include a valve assembly disposed within a stent, and first and second cuffs. The stent may extend in a longitudinal direction from an inflow end to an outflow end. The first cuff may be annularly disposed adjacent the stent. The second cuff may have a proximal edge facing toward the inflow end of the stent and a distal edge facing toward the outflow end of the stent. The second cuff may be annularly disposed about the stent radially outward of the first cuff. The distal edge of the second cuff may be coupled to the first cuff and/or the stent at a plurality of locations to form a pocket(s) between the first and second cuffs. The proximal edge of the second cuff may be coupled to first cuff and/or to the stent at a spaced distance from the inflow end of the stent.

Elevated outer cuff for reducing paravalvular leakage and increasing stent fatigue life

A spherical reamer comprises a cutting element having a support member and at least one circumference cutting member built on it. The cutting member can be characterized by edge configuration, geometric parameters or further by positional parameters, respectively. All variations of the parameters above lead various types of the cutting elements and methods of including self- assembling and/or 'One Size Cutting Element for Assembling Several Size of Reamers' in order to assembling either reusable or disposable reamer.

Hemispherical reamer having circular cutting members and methods of making the same

A prosthetic heart valve includes a collapsible stent extending from an inflow end to an outflow end, and a cuff having an inflow end an outflow end. The stent includes first and second circumferential rows of cells defined by first and second pluralities of struts, respectively. The second circumferential row is positioned closer to the outflow end of the stent than the first circumferential row. At least one cell in the second circumferential row includes by a first strut opposed to a fourth strut and a second strut opposed to a third strut. A bridging feature in at least one cell in the second circumferential row includes first and second supplemental struts extending across an intermediate portion of the cell. The outflow end of the cuff is coupled to the stent along the bridging feature.

Stent cell bridge for cuff attachment

Methods and apparatus for preparing at least a hemispherical surface with a desired dimension have been disclosed. The method includes at least two steps: a primary cutting mode for mostly reaming a lower portion of the target site, which enveloped area from the pole to intermediate latitude and a finishing cutting mode for reaming either an upper portion or an entire area of the site by less number of times of rotation, respectively. The intermediate latitude locates between the pole and the equator of hemisphere.

Methods and apparatus for preparing a hemispherical surface

A prosthetic heart valve includes a collapsible and expandable stent including a plurality of struts forming cells, the stent having a proximal end, a distal end, an annulus section adjacent the proximal end, an aortic section adjacent the distal end, and a transition section disposed between the annulus section and the aortic section, the aortic section having a larger diameter than the annulus section. The heart valve further includes a valve assembly disposed entirely in the annulus section of the stent for controlling the flow of blood through the stent, the valve assembly including a plurality of leaflets, and a cuff, the cuff being disposed on a surface of the stent and extending fully over at least two rows of cells of the stent.

Self-expanding heart valves for coronary perfusion and sealing

A therapeutic device includes a prosthetic heart valve including a collapsible and expandable stent having an aortic section and an annulus section, and a valve assembly disposed within the annulus section of the stent, the valve assembly including a plurality of leaflets; and a graft coupled to the aortic section of the stent. The graft has a body and at least one lining disposed on the body and defining a lumen therethrough.

Recapturable valve-graft combination and related methods

An implantation device for a prosthetic heart valve includes a valve holder for maintaining the prosthetic heart valve in a closed configuration and at least one protective sheet coupled to the valve holder, the at least one protective sheet being configured to cover a leaflet of the heart valve during implantation.

Valve holder with leaflet protection

A mandrel for molding polymer valve leaflets for heart valve prostheses is disclosed, including a body portion including an outer surface with ridges and contoured surfaces corresponding to the leaflets, the upper edge of the contoured surfaces corresponding to the free upper edge of the leaflets, and the mandrel including a mandrel extension above the body portion, and a gap extending around the mandrel between the upper edge of the contoured surface and the mandrel extension. A process for producing these polymer valve leaflets is also disclosed by dip coating with this mandrel and removing the polymer film created at the gap, preferably by applying suction or blowing thereto.

Growing community of inventors

Shoreview, MN, United States of America

Xue Mei Li