Massachusetts Institute of Technology

Mayo Foundation for Medical Education and Research

The General Hospital Corporation

Beth Israel Deaconess Medical Center, Inc.

Xuanhe Zhao

Hyunwoo Yuk

Shaoting Lin

Lee A Weinstein

Evelyn N Wang

Sungwoo Yang

Bikramjit S Bhatia

Lin Zhao

Thomas Alan Cooper

Elise M Strobach

Yoonho Kim

Christoph Nabzdyk

Gang Paul Chen

Gang Chen

Xinyu Mao

Heejung Roh

John H Lienhard

Timothy Kuan-Ta Lu

Christopher Tam Nguyen

Yoichiro Tsurimaki

Clara Park

Akihisa Inoue

Sarah J Wu

Ellen T Roche

Xiaoyu Chen

Georgios Theocharidis

Xinyue Liu

Tzu-Chieh Tang

Eléonore Claire Tham

Omar Labban

Grace Goon

German A P Hernandez

Teng Zhang

A shape memory adhesive material for adhering and contracting wounds, particularly diabetic wounds, to facilitate their closure and healing. The shape memory adhesive is pre-stretched and dried to provide an adhesive structure with a pre-programmed strain, wherein the adhesive is capable of rapid robust adhesion followed by predictive contraction upon contact with a wet surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.

Shape memory adhesive materials for diabetic wound healing

Described herein are window retrofits including a monolithic silica aerogel slab having (i) an average haze value of <5% as calculated in accordance with ASTM standard D1003-13 and (ii) a U-factor of <0.5 BTU/sf/hr/° F., and a transparent polymer envelope sealed at an internal pressure of ≤1 atmosphere, wherein the monolithic silica aerogel slab is encapsulated in the transparent polymer envelope. The monolithic aerogel slab can have a transmittance>94% at 8 mm thickness. The window retrofit can be bonded to a glass sheet.

Energy efficient soundproofing window retrofits

Bioadhesive materials and methods for adhering biological tissues and blood vessels in a minimally invasive manner, wherein the bioadhesive materials are in folded bioadhesive sleeve configurations or in injectable bioadhesive forms adapted for delivery using minimally invasive procedures. The folded bioadhesive sleeve is disposed on the distal portions of a variety of minimally invasive devices for insertion to a target tissue site, then deployed and adhered to the target tissue site through actuation of the minimally invasive device. The injectable bioadhesive is disposed in a syringe and delivered to a target site via a catheter, then adhered to the target tissue by actuation of a minimally invasive device. Precise placement and adhesion to the target tissue site can be successfully accomplished solely through the actuation of the minimally invasive devices without the use of additional devices to assist in placement or actuation of the bioadhesive materials.

Bioadhesive materials and minimally invasive methods for adhering tissues with bioadhesive materials

A method of adhering wet tissues together includes providing a dry adhesive material that contains one or more hydrophilic polymers, one or more amine coupling groups, and one or more cross linkers. The method including the steps of placing the dry adhesive material in contact with one or more wet tissue surfaces; allowing the dry adhesive material to absorb liquid from the one or more wet surfaces to thereby swell the adhesive material; allowing instant crosslinking by intermolecular interactions between the adhesive material and the one or more wet surfaces; and allowing quick covalent crosslinking between the adhesive material and the one or more wet surfaces.

Dry double-sided material for adhesion of wet tissues and devices

A tissue adhesive material that provides fast and robust adhesion even on tissue surfaces covered in bodily fluids. The tissue adhesive material is formed of a hydrophobic matrix and a plurality of bioadhesive microparticles dispersed within the hydrophobic matrix configured such that disposing the adhesive material directly on a fluid covered surface and applying pressure causes the (a) hydrophobic matrix to repel the fluid, (b) the bioadhesive particles to compress forming an adhesive layer, and (c) the bioadhesive particles to form temporary crosslinks followed by covalent crosslinks with the surface.

Body fluid resistant tissue adhesives

A biorobotic hybrid heart that preserves organic intracardiac structures and mimics cardiac motion by image-guided replication of the cardiac myofiber architecture of the left ventricle with an active synthetic myocardium that drives the motion of the heart. The active soft tissue mimic is adhered to the organic endocardial tissue in a helical fashion using a custom-designed adhesive to form a flexible, conformable, and watertight organosynthetic interface.

Organosynthetic dynamic heart model

The present disclosure generally relates to a stretchable anti-fogging tape (SAT) that can be applied to diverse transparent materials with varied curvatures for persistent fogging prevention. The SAT comprises three synergistically-combined transparent layers: i) a stretchable middle layer with high elastic recovery to keep transparent materials tightly bound; ii) an anti-fogging top layer to impart hydrophilicity to transparent materials; and iii) an adhesive bottom layer to form robust yet reversible adhesion between transparent materials and SATs. The SAT can be configured to have water condensate form a predominantly continuous film thereon in response to a high humidity environment At least two applications are demonstrated, including the SAT-adhered eyeglasses and goggles for clear fog-free vision, and the SAT-adhered condensation cover for efficient solar-powered freshwater production.

Transparent, anti-fog tape or film and related devices and methods

Adhesion of conducting polymers on diverse insulating and conductive substrates via a hydrophilic adhesion layer, where one or more functional groups may be disposed between the substrate and the hydrophilic adhesion layer. Adhesion of the conducting polymers on the substrates is such that adhesion is maintained or substantially maintained in wet physiological environments.

Strong adhesion of conducting polymers on diverse substrates

A dry shape memory adhesive material for adhering a target surface in the presence of fluid and for providing tunable mechanical contraction of an adhered surface. The dry shape memory adhesive material is pre-stretched and dried to provide an adhesive structure that implements a hydration-based shape memory mechanism to achieve both uniaxial and biaxial contractions of the adhered surface. According to preferred embodiments, the shape memory adhesive material includes a combination of one or more hydrophilic polymers or copolymers, one or more amine coupling group, and one or more cross linkers.

Hydration-based shape memory adhesive materials and methods of making

An adhesive material that provides fast and robust adhesion on wet surfaces, where the adhesion formed is detachable on-demand. The adhesive material is formed of one or more hydrophilic polymers or copolymers grafted with one or more amine coupling groups via a plurality of cleavable physical bonds and/or cleavable covalent bonds and one or more cross linkers. Application of the adhesive material on a wet surface causes the adhesive material to absorb liquid to thereby swell the adhesive material to form a layer of hydrogel, resulting in the formation of temporary crosslinks followed by covalent crosslinks with the surface. Introducing a triggering agent cleaves the cleavable physical bonds and/or cleavable covalent bonds to allow for non-traumatic detachment of the adhesive material from the surface.

Adhesive material with triggerable on-demand detachment

Dry adhesive materials, particularly in the form of a film or tape, for adhering one or more wet surfaces comprising: (i) one or more hydrophilic polymers; (ii) one or more amine coupling groups, and (iii) one or more cross linkers. The dry adhesive material, when placed in contact with the one or more wet surfaces, absorbs liquid from the one or more wet surfaces, swells to form temporary crosslinking with the wet surface, and forms covalent crosslinking with the one or more wet surfaces.

Provided herein, in some embodiments, are hydrogel-elastomer and hydrogel-alginate devices, compositions and associated methods to encapsulate living cells.

Materials and devices containing hydrogel-encapsulated cells

Robotic devices and methods for performing minimally invasive procedures on the vascular system, particularly cerebrovascular and endovascular neurosurgical procedures, where a submillimeter-scale continuum robotic device is configured and adapted for active steering and navigation based on external magnetic actuation. The submillimeter-scale continuum robotic device includes an elongate body having an inner core and an outer shell, where the outer shell is fabricated of an elastomeric material having a plurality of ferromagnetic particles dispersed therein.

Magnetically steerable continuum robotic guidewires for neurovascular applications

Described herein are window retrofits including a monolithic silica aerogel slab having (i) an average haze value of &#x3c;5% as calculated in accordance with ASTM standard D1003-13 and (ii) a U-factor of &#x3c;0.5 BTU/sf/hr/&#xb0; F., and a transparent polymer envelope sealed at an internal pressure of &#x2264;1 atmosphere, wherein the monolithic silica aerogel slab is encapsulated in the transparent polymer envelope. The monolithic aerogel slab can have a transmittance &#x3e;94% at 8 mm thickness. The window retrofit can be bonded to a glass sheet.

Growing community of inventors

Allston, MA, United States of America

Xuanhe Zhao