Shearwater Corporation

Xuan Zhoa

Michael David Bentley

J Milton Harris

Xiaoming Shen

A water soluble polymer is provided having two or more oligomers linked to each other by hydrolytically degradable carbonate linkages. The polymer can be hydrolytically degraded into oligomers (e.g., oligomers of ethylene oxide) under physiological conditions. The polymer can be conjugated to biologically active agents such as proteins or peptides to impart improved water solubility, reduced immunogenicity, reduced rate of renal clearance, and increased stability. The polymer is useful in making hydrolytically degradable hydrogels which can be used in drug delivery and related biomedical applications. One example of the polymer is a poly(ether carbonate) of the formula X&mdash;O&mdash;&lsqb;(&mdash;CH CH &mdash;O&mdash;) &mdash;CO &mdash;&rsqb; &mdash;(CH CH )) -y where X and Y are independently H, alkyl, alkenyl, aryl, or a reactive moiety, and at least one of X and Y is a reactive moiety.

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Huntsville, AL, United States of America

Xuan Zhoa