Shanghai United Imaging Healthcare Co., Ltd.

Shanghai Epimab Biotherapeutics Co., Ltd.

Xuan Wu

Jonathan S Maltz

Supratik Bose

Chengbin Wu

Hongcheng Yang

Shiyong Gong

The present disclosure provides a system and method for couch position calibration. The method may include obtaining one or more first images of a couch at one or more first locations in a first device, each of the one or more first images corresponding to one of the one or more first locations, wherein the couch includes a mark, and the mark intersects a first reference plane of the first device at a plurality of first points of the mark; determining, in each of the one or more first images, a first position of a representation of each of the plurality of first points; obtaining correlation information between the first position and actual position of each of the plurality of first points; and determining one or more calibration images based on the correlation information and the one or more first images.

Systems and methods for generating calibration images for couch position calibration

High-affinity antibodies recognizing Programmed Death Ligand-1 (PD-1) and Lymphocyte Activation Gene 3 protein (LAG-3) are disclosed. Binding sites from humanized anti-PD-1 and anti-LAG-3 antibodies are incorporated into a Fabs-in-Tandem Immunoglobulin format without significant loss of binding affinity, and the resultant bispecific, multivalent binding proteins are able to bind to both PD-1 and LAG-3 simultaneously. Such bispecific FIT-Ig binding proteins are useful for treatment of cancer.

High affinity antibodies to PD-1 and LAG-3 and bispecific binding proteins made therefrom

Growing community of inventors

Shanghai, China

Xuan Wu