Chinese Academy of Sciences

Shanghai Huaming Power Equipment Co., Ltd

Shanghai Lead Discovery Pharmaceuticals Limited Company

Huawei Technologies Co., Limited

Xu Shen

Jing Lan Chen

Lei Han

Hualiang Jiang

Hong Ding

Hong Tao Liu

Fei Ye

Lihong Hu

Kaixian Chen

Jingkang Shen

Tao Sun

Jianping Zuo

Jianhua Shen

Bing Xiong

Xiaomin Luo

Liguang Lou

Lili Chen

Riming Xiao

Yong Shao

Donglu Bai

Yiming Yang

Haibin Luo

Hankun Zhang

Chunshan Gui

Yifu Yang

Xianhan Zhuang

Xuchang He

Disclosed is a suspensible external combined on-load tap changer, including: a switch box, a switch body and a motor mechanism, a top box wall of the switch box being opened with a top opening, a top box cover being mounted on the top opening, wherein the switch body is detachably mounted in the switch box and is entirely lifted in and lifted out by the top opening; and the motor mechanism is connected with the switch body in a driving manner. The switch body in the present invention uses a hoisting structure, and the top box wall of the switch box is opened with a top opening with a size large enough, so that the switch body is directly lifted in and lifted out of the switch box from the top opening, and installation and maintenance are easier.

External on-load tap changer

A change-over structure disposed between a moving contact and a static contact of a tap selector includes an insulation changer base plate, static contacts which are fixed on the insulation changer base plate in at least one column at intervals, the inner ends of the static contacts are electrically connected to respective tap windings of a transformer, rotation shafts, each comprising moving contacts that are evenly distributed on each of the rotation shafts and are electrically connected to each other, and arc-shaped conductors corresponding to the static contacts in at least one column. Each of the arc-shaped conductors and outer ends of the static contacts are disposed at the same circumference with a center of one of the rotation shafts as a circle center. When one of the moving contacts is changed over between the two static contacts, another moving contact is electrically connected to the arc-shaped conductor.

Change-over structure between moving contact and static contact of tap selector

The invention provides vinblastine derivatives represented by the following formula 1 or their physiologically acceptable salts, their preparation, use and pharmaceutical compositions comprising the said derivatives. The said vinblastine derivatives show inhibiting activities against tumor cell lines and can be used as medicaments for treating malignant tumors. 

Vinblastine derivatives, their preparation, use and pharmaceutical compositions comprising the said derivatives

The present invention discloses 3D-structure of SARS-CoV Viral 3CL Protease obtained through molecular simulation. The 3D-structure is used as a drug target for screening the existing medical database CMC (Comprehensive Medicinal Chemistry, MDL Information System, Inc.), and a group of compounds which have the activity of inhibiting SARS-CoV virus 3CL Protease are found. Cinanserin was tested at molecular and viral levels, and it was found to be able to inhibit the SARS-CoV viral 3CL protease and SARS-CoV viruses. Cinanserin analogs were synthesized and tested at molecular and viral levels, they were found to be able to inhibit the SARS-CoV virus 3CL Protease and SARS-CoV viruses, and may be used for treating and/or preventing SARS-CoV virus infection.

3D-structure model of SARS coronavirus 3CL protease and anti-SARS drugs

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Shanghai, China

Xu Shen